丹参对大鼠烧伤后细胞的保护作用  

Tbe protective effect of labiate on rat cells post burn

作　　者：邱振中[1] 李锐[1] 

机构地区：[1]中国人民解放军第三医院烧伤科,陕西宝鸡721004

出　　处：《中国烧伤创疡杂志》2005年第2期97-99,共3页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的:探讨丹参与大鼠烧伤后细胞的保护作用。方法:68只SD大鼠随机分为健康对照组(A)、烧伤对照组(B)、烧伤治疗组(C)。B组和C组造成20%总体表面积Ⅲ度烧伤。在伤后2、6、12小时,动态检测肠组织丙二醛(MDA)和超氧化物歧化酶(SOD)含量、血浆中内皮素(ET)、一氧化氮(NO)及乳酸脱氢酶(LDH)水平的变化。结果:(1)B、C组肠组织中超氧化物歧化酶(SOD)水平低于A组,C组与A组可差异无统计学意义(P>0.05);(2)B、C组肠组织丙二醛(MDA)含量显著高于A组(P<0.05),C组显著低于B组(P<0.05);(3)B、C组血浆中内皮素(ET)、一氧化氮(NO)及乳酸脱氢酶(LDH)含量显著高于A组(P<0.05);C组低于B组。结论:丹参能减轻大鼠烧伤后细胞损伤;丹参能通过提高SOD降低MDA、ET和NO的生成等途径,减轻烧伤后细胞损伤;有可能减轻烧伤后全身炎症反应综合症和多器官功能障碍综合症,提高治愈率。Objective: To study the protective effect of labiate on rat cells post burn. Method: 68 Spregue - Dawley rats were randomly divided into control group (A), burn group (B) and treatment group (C). Rats in groups B and C were burned to full- thickness with a total area of 20%TBSA. Dynamic changes in the plasma levels of endothelin (ET), nitric oxide (NO) and lactic dehydrogenase (LDH) were determined at different time points post injury and in the meantime, malondialdehyde (MDA) and superoxide dismutase (SOD) levels in intestine tissue were also determined. Result: 1. In groups B and C, the levels of SOD in intestine tissue were lower than that in group A. But the difference between group A and group C was not significant. 2. In groups B and C, the levels of MDA in intestine tissue were much higher than that in group A (P<0. 05); and in group C, MDA level was much lower than in group B (P<0. 05). 3. The plasma levels of ET, NO, and LDH in groups B and C were increased obviously post injury (P < 0. 05), but in group C, these values were lower than that in group B. Conclusion: Labiate has protective effect on rat cells post burn. It increases the level of SOD and decreases that of MDA, ET, and NO in plasma and as a result, it lessens the damage of cells. Therefore, it may also lessen the systemic inflammation reaction syndrome and multiple organ dysfunction syndrome poet thermal injury.

关 键 词：烧伤 丹参 内皮素 乳酸脱氢酶 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学]