Synthesis and Chromatographic Properties of New β-Cyclodextrin Derivatives with α-Schiff Base Groups for HPLC  

作　　者：MinFANG ZhiMingZHOU AiQinLUO 

机构地区：[1]SchoolofChemicalEngineeringandtheEnvironment,BeijingInstituteofTechnology,Beijing100081

出　　处：《Chinese Chemical Letters》2005年第6期789-792,共4页中国化学快报（英文版）

摘　　要：Cyclodextrin 1 was directly oxidized to the corresponding monoaldehyde 2 on their primary faces by cyclized 2-iodoxybenzoic acid(IBX) in DMSO, followed by the synthesis of β-cyclodextrin derivatives bearing Schiff-base group 3. A new chiral stationary phase(BCDS 6) was then prepared by immobilization of β-cyclodextrin derivative with α-Schiff base group onto the surface of sillica gel. A series of compounds with amino groups were readily separated using this CSP. Methanol and acetonitrile were tested as the mobile phase while the influence of temperature and the addition of aqueous triethylammonium acetate buffer to the mobile phase was also innvestigated. Ferrocene ligand with Schiff-based groups have been separated satisfactorilly on BCDS column.

关 键 词：CYCLODEXTRIN Schiff base ferrocene. 

分 类 号：O626[理学—有机化学]