冠心病患者循环血中肿瘤坏死因子、内皮细胞的变化及其意义  

CHANGES OF CIRCULATING ENDOTHELIAL CELLS,PLASMA TUMOR NECROSIS FACTOR IN PATIENTS WITH CORONARY HEART DISEASE

作　　者：杨丽霞[1] 张崇德 祝善俊[1] 杨映波 

机构地区：[1]中国人民解放军成都军区昆明总医院心内科,中国人民解放军第三军医大学第二附属医院心内科,中国人民解放军第三军医大学第三附属医院创伤科

出　　处：《中国循环杂志》1994年第9期519-521,共3页Chinese Circulation Journal

摘　　要：为探讨内皮细胞损伤和细胞因子在冠心病的发病学意义，我们以双抗体夹心法检测血浆肿瘤坏死因子（ＴＮＦ）含量，以循环内皮细胞（ＣＥＣ）数量作为在体判断血管内皮细胞损伤的指标，ＣＥＣ经免疫荧光ＶＩＩＩ－Ｒ：Ａｇ鉴定。结果显示，３６例冠心病患者外周血中ＣＥＣ数、ＴＮＦ含量高于３０例正常人，尤以不稳定性心绞痛和急性心肌梗塞组增高显著（Ｐ＜０。００１）。提示ＴＮＦ可能参与冠心病的病理过程。In order to explore the significance of cellular factor and endothelial injury in the pathogenesis of coronary heart disease(CHD), plasma level of tumor necrosis factor(TNF) was measured by double-antibody sandwich method. The number of circulating endothelial cells (CEC) was counted as an indicator of the injury of vascular endothelial cells(VEC) in vivo, which were identified by fluorescein-labeled anti-human antibody to factor Ⅷl related antigen. The results showed that the number of CEC, plasma TNF in 36 patients with CHD were significantly higher than those in 30 normal volunteers (p<0. 01 or 0.001),especially in patients with unstable angina pectoris and acute myocardial infarction.It is suggested that the elevation of circulating TNF might participate in the pathophysiology of CHD.

关 键 词：冠心病 肿瘤坏死因子 循环内皮细胞 

分 类 号：R541.4[医药卫生—心血管疾病]