原发性高血压的免疫遗传学研究的探讨  

PRELIMINARY IMMUNOLOGICAL GENETIC STUDY OF ESSENTIAL HYPERTENSION

作　　者：孙宁玲[1] 王静毅[1] 师淑敏[1] 陈源源[1] 阎文瑛[1] 包丕云 

机构地区：[1]北京医科大学人民医院,内蒙古医学院流行病室

出　　处：《中国循环杂志》1994年第12期739-742,共4页Chinese Circulation Journal

基　　金：国家高等教育委员会博士基金

摘　　要：对有高血压遗传家族史患者５０例（Ａ组），无遗传史高血压患者２１例（Ｂ组）以及正常健康人１００例（Ｃ组）进行免疫遗传学的部分检查：①人类白细胞抗原（ＨＬＡ）的检查结果显示，Ａ组Ｂ７５－ＤＱ７抗原频率明显升高，Ｂ７５－ＤＱ７呈连锁不平衡；Ｂ组Ｂ８抗原频率增加，Ａ２４－ＤＱ２连锁。家系单倍型分析发现，Ａ组的同胞中父母单倍型呈非随机分布。②遗传度分析结果显示，Ａ组的平均遗传度为５９．８８±８．１０％，表明遗传因素在高血压易患变异上起重要作用。③遗传方式的研究发现，原发性高血压属多基因遗传。④淋巴细胞亚群分析结果显示，ＣＤ４／ＣＤ８比值升高，淋巴Ｂ细胞百分率增高，同时伴有免疫循环复合物增加。因此，本研究认为，原发性高血压的形成与发展与免疫遗传的变化有关。An immunological genetic study had been performed on 50 cases of inheritable essential hypertension(group A),21 cases of noninheritable essential hypertension(group B),and 100 cases of normal subjects(group C).The results showed that:① antigen frequency of B75,DQ7 significantly increased and B75-DQ7 presented linkage imbalance in group A;antigen frequency of B8 increased and A24-DQ2 linked up in group B;nonrandomized distribution was found in haploidy of parents in group A analyzed by family spectrum;② the weighed mean of heritability and standard error of group A being 59.88±8.10%.It indicates that genetic factor might play an important role in hypertensive variance;③ multigenetic inheritable mode was found in essential hypertension by this study;④the ratio of CD4/CD8 and the percentage of B lymphocyte increased and accompanied with increased immunological complex.Therefore,this study suggests that the formation and development of essential hypertension are related to immunological genetic factors.

关 键 词：高血压 白细胞抗原 T淋巴细胞 免疫遗传学 

分 类 号：R544.103[医药卫生—心血管疾病]