Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports)  

作　　者：ZhangJianliang QinYong-wen ZhengXing QiuJianli CaoJiang XuRong-liang 

机构地区：[1]DepartmentofCardiovasology,ChanghaiHospital,Shanghai200433,China

出　　处：《第二军医大学学报》2005年第4期459-459,共1页Academic Journal of Second Military Medical University

摘　　要：Objective:To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention,diagnoses and treatment of diabetes induced by indapamide.Methods:Four cases of essential hypertension patients(1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations. Results:Afer 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/d) and fosinopril (10 mg/d) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient,glucose levels of all patients increased and achieve criteria of diabetes diagnoses.After 3-to 13-month period of therapy without indapamide,glucose levels of all patients decreased and diabetes disappeared.Conclusion:Therapy with indapamide may induce diabetes in essential hypertension patients.After stopping indapamide,glucose tolerance impairing may be reversed.Objective:To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention,diagnoses and treatment of diabetes induced by indapamide.Methods:Four cases of essential hypertension patients(1 male and 3 females) were observed through process of therapy with indapamide and laboratory investigations. Results:Afer 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/d) and fosinopril (10 mg/d) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient,glucose levels of all patients increased and achieve criteria of diabetes diagnoses.After 3-to 13-month period of therapy without indapamide,glucose levels of all patients decreased and diabetes disappeared.Conclusion:Therapy with indapamide may induce diabetes in essential hypertension patients.After stopping indapamide,glucose tolerance impairing may be reversed.

关 键 词：糖尿病 高血压 治疗方法 病理机制 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]