2种组胺受体拮抗剂对低温诱发的肉鸡肺动脉高压的影响  

Effects of Two Histamine Receptor Antagonists on Pulmonary Hypertension in Broiler Chickens

作　　者：刘文菊[1] 乔健[1] 欧德渊[1] 范春艳[1] 杨鹰[1] 李静[1] 高铭宇[1] 

机构地区：[1]中国农业大学动物医学院病理组,北京100094

出　　处：《畜牧兽医学报》2005年第4期407-411,共5页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金资助项目(30070567;30371063)

摘　　要：为探讨组胺H1受体拮抗剂扑尔敏和H2受体拮抗剂西咪替丁对低温诱发的肉鸡肺动脉高压的影响,并由此推测组胺在低温诱发的肉鸡肺动脉高压形成过程中的作用。140只17日龄AA肉鸡随机分为4组。(1)常温组:40只在常温条件下饲养(22～23℃),每日注射生理盐水2次;(2)低温组:40只在低温环境中饲养(9～11℃),每日注射生理盐水2次;(3)扑尔敏组:40只在低温环境中饲养(9～11℃),每日注射扑尔敏2次;(4)西咪替丁组:20只在低温环境中饲养(9～11℃),于24日龄至38日龄期间每日注射西咪替丁2次。分别于低温处理后1周(24日龄)、2周(31日龄)、3周(38日龄)、4周(45日龄)从常温组,低温组,扑尔敏组中各随机抽取10只,西咪替丁组在低温处理后2周(31日龄)、3周(38日龄)各随机抽取10只,称取体重,然后利用右心导管法测定肺动脉压(PAP),并测定红细胞压积(PCV),腹水心脏指数(AHI)。结果发现:(1)24日龄、31日龄、38日龄时,低温组肺动脉收缩压,舒张压显著高于(P<0105)或极显著高于(P<0101)同日龄常温组。24日龄时扑尔敏组肺动脉收缩压显著低于(P<0105)同日龄低温组。38日龄时西咪替丁组肺动脉收缩压,舒张压极显著低于(P<0101)同日龄低温组。(2)24日龄、31日龄、38日龄、45日龄时,低温组PCV极显著高于(P<0101)同日龄常温组。Effect of two histamine receptor antagonists, chlorphenamine maleate and cimetidine, on pulmonary hypertension (PH) induced by low ambient temperature in broiler chickens were investigated. One hundred and forty 17-day broiler chickens were randomly divided into four groups.(1) normal temperature group(NT): forty birds were reared at 22 ~23 ℃ and normal saline was given twice by intramuscular injection each day.(2)Low ambitent temperature group(LT) : forty birds were reared at 9~11 ℃ and normal saline was given twice by intramuscular injection each day.(3)Chlorphenamine maleate group in low ambient temperature (CMLT): forty birds were reared at 9~11 ℃ and chlorphenamine maleate was given twice by intramuscular injection each day.(4)Cimetidine group in low ambient temperature (CLT):twenty birds were reared at 9~11 ℃ and cimetidine was given twice each day by intramuscular injection from 24 to 38 days of age. At 24, 31, 38, 45 days of age, 10 birds were randomly taken from each group except CLT.At 31, 38 days of age,10 birds were randomly taken from CLT. The following three parameters were measured : the pulmonary artery pressure (PAP) by right cardiac catheter,the ascites heart index(AHI) and the packed cell volume (PCV).The results were as follows:(1)At 24, 31, 38 days of age, the pulmonary artery systolic pressure and diastolic pressure of LT were significantly higher than that of NT (P<0.05 or P<0.01). The pulmonary artery systolic pressure of CMLT was significantly lower than that of LT at 24 days of age (P<0.05). The pulmonary artery systolic pressure and diastolic pressure of CLT were significantly lower than that of LT at 38 days of age (P<0.01). (2) The PCV of LT was significantly greater than that of NT ( P<0.01) at 24, 31, 38, 45 days of age.At 24 days of age, the PCV of CMLT was significantly lower than that of LT (P<0.05). At 31 days of age, the PCV of CMLT was significantly higher than that of LT (P<0.01).(3) The AHI of LT was significantly greater than that of NT (P<0.05) at 45 days of age.Th

关 键 词：肺动脉高压 诱发 组胺 H2受体拮抗剂 H1受体拮抗剂 西咪替丁 低温环境 肺动脉压 扑尔敏 生理盐水 低温处理 随机抽取 右心导管法 红细胞压积 收缩压 PCV 形成过程 AA肉鸡 常温条件 心脏指数 发生发展 舒张压 日龄 饲养 

分 类 号：S858.31[农业科学—临床兽医学] TS254.7[农业科学—兽医学]