泽泻抑制尿草酸钙结石形成活性成分的2DNMR分析  

Analysis of Active Ingredients in Alisma orientalis (Sam.)Juze Extract for Inhibiting Formation of Urinary Oxalate Calcium Calculi by 2D NMR

作　　者：周雪峰[1] 尹仁杰[1] 阮汉利[1] 张勇慧[1] 皮慧芳[1] 赵晓亚[1] 吴继洲[1] 

机构地区：[1]华中科技大学同济药学院,湖北武汉430030

出　　处：《波谱学杂志》2005年第2期195-200,共6页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金资助项目(39970891)

摘　　要：从中药泽泻[Alismaorientalis(Sam.)Juzep.]抑制尿草酸钙结石形成的活性部位分离得到3个化合物,并鉴定为alisolF24-acetate、alisolA24acetate和alismoxide.首次应用1H-1HCOSY、HMQC和HMBC等2DNMR技术对alisolF24-acetate的氢信号进行全归属.Three compounds were isolated from the active fraction of Alisma orientalis (Sam.) Juze extract that inhibits urinary oxalate calcium calculi formation, and identified to be alisol F 24-acetate, alisol A 24-acetate and alismoxide. The proton chemical shifts of alisol F 24-acetate were assigned by using 2D NMR techniques including {}+1H-+1H COSY、HMQC and HMBC.

关 键 词：草酸钙 NMR分析 活性成分 石形 抑制 泽泻 尿 NMR技术 活性部位 COSY HMBC HMQC 化合物 全归属 氢 

分 类 号：O626[理学—有机化学] TQ262.2[理学—化学]