环氧化酶-2抑制剂体外筛选模型在药物抗炎机制研究中的应用  

Cyclooxygenase-2 inhibitors in vitro screening model in anti-inflammation of drugs

作　　者：张娟[1] 王旻[1] 张玉彬[1] 

机构地区：[1]中国药科大学分子生物学教研室,南京210009

出　　处：《中南药学》2005年第3期144-146,共3页Central South Pharmacy

摘　　要：目的考察化合物ZA76和中药单体LM、XR和HQ对环氧化酶2(COX-2)的影响。方法利用作者建立的COX-2抑制剂体外筛选模型。结果发现化合物ZA76对COX-2有较强抑制作用,中药单体LM、XR对COX-2有一定的抑制作用,HQ对COX-2有较弱抑制作用。结论可以应用模型进行COX-2抑制剂的筛选,并能阐明部分抗炎药物的作用机制。OBJECTIVE To investigate the influence of chemical ZA-76 and China traditional medicine monomer LM,XR,and HQ on COX-2 enzyme activity.METHODS The in vitro screening model for cyclooxygenuse inhibifors that was established by the author before was used. RESULTS ZA-76 could selectively inhibit COX-2, LM and XR could inhibit COX-2 to some degree,and HQ had weak inhibition on COX-2. CONCLUSIONS The model can be used to screen COX-2 selective inhibitors. It can also clarify the anti-inflammatory mechanism of some drugs.

关 键 词：环氧化酶-2 前列腺素E2 炎症 

分 类 号：R965.1[医药卫生—药理学]