荧光光谱法研究清开灵注射液热稳定性  

Thermal stability of Qingkailing injection by fluorimetry

作　　者：邓三尧[1] 陈小康[2] 

机构地区：[1]广东省粤北人民医院,韶关512026 [2]韶关学院化学系,韶关512005

出　　处：《中南药学》2005年第3期146-147,共2页Central South Pharmacy

基　　金：广东高校自然科学研究基金项目(Z02078);韶关市重点科技项目

摘　　要：目的对清开灵注射液热稳定性进行初步探讨。方法采用荧光光谱法考察清开灵注射液在不同温度条件、不同存放时间的荧光谱图变化。结果恒温(40、80℃)条件下、不同存放时间的热稳定性的荧光谱图,呈现出规律性的变化,通过其谱图的分析,能够反映出不同温度下时间分辨光谱的差异、谱峰强度的差异及不同厂家成品间热稳定性的差异。结论荧光光谱法能够准确地对中药注射剂的热稳定性进行判定,为中药注射剂稳定性的研究和控制提供一种新的途径。OBJECTIVE To determine the thermal stability of Qingkailing injection. METHODS The fluorescence technique was used. RESULTS The thermal stabilities of Qingkailing injection at 40 ℃ and 80 ℃ at different preserving time were investigated with fluorimetry in this paper. A regular change emerged on their fluorescence spectrum . By analyzing the spectrum,we found the differences in time -distinguishing fluorescence spectrum, the intension of peak and thermal stability of products from different factories at different temperatures. CONCLUSIONS The thermal stability of Chinese tradional injection can be studied accurately with fluorimetry and the paper provided a new way to study and control the thermal stability of Chinese tradional medicine injection.

关 键 词：荧光光谱 清开灵注射液 热稳定性 

分 类 号：R927.11[医药卫生—药学]