辛伐他汀干预治疗对不稳定型心绞痛患者颈动脉粥样硬化及血浆高敏C反应蛋白的影响  

Influnence of Simvastatin on arteriosclerosis plaque of the carotid artery and high- sensitivity C-reactive protein concentrations in patients with unstable angina

作　　者：杭娟[1] 李秋荣[1] 蒋宝琦[1] 

机构地区：[1]北京大学深圳医院,深圳518032

出　　处：《中南药学》2005年第3期148-150,共3页Central South Pharmacy

摘　　要：目的探讨冠心病不稳定型心绞痛(unstableangina,UA)患者应用辛伐他汀干预治疗对颈动脉粥样硬化和血浆高敏C反应蛋白(hsCRP)的影响。方法将72例冠心病不稳定型心绞痛患者随机分为辛伐他汀组(35例)和常规治疗组(37例),辛伐他汀组在常规治疗组基础上加服辛伐他汀(40mg·d-1),治疗前和治疗后6个月、12个月分别检测两组血浆hsCRP、纤维蛋白原水平,并以彩色多普勒超声测定颈动脉内膜厚度、血流参数及颈动脉粥样斑块的变化。结果辛伐他汀组患者干预治疗6个月、12个月后血浆hsCRP浓度、纤维蛋白原水平较治疗前显著降低(P<0.05),颈动脉内膜厚度减小,颈动脉粥样斑块面积缩小,颈动脉血流参数改善,且12个月后上述变化更为明显,与治疗前及常规治疗组比较,有显著性差异(P<0.01)。结论不稳定型心绞痛患者辛伐他汀干预治疗可显著降低血浆hsCRP、纤维蛋白原水平,对防治早期动脉粥样硬化及稳定斑块起一定作用。OBJECTIVE To explore the influnce of Simvastatin on arteriosclerosis plaque of carotid artery and high-sensitivity C-reactive protein(hs-CRP) ,fibrinogen concentrations in patients with unstable angina(UA). METHODS Seventy-two patients with UA were randomly divided into two groups.One group accepted Simvastatin (40 mg·d~ -1) besides the routine therapy. For all patients,the concentrations of plasma triglyceride(TG),total cholesterol, LDL-cholesterol, HDL-cholesterol,hs-CRP and fibrinogen concentrations were detected in fasting state before the treatment and 6 months and 12 months after the treatment.The intima-media thickness(IMT),blood flow parameter, and arteriosclerosis plaque of the carotid artery were measured with Doppler ultrasonograph. RESULTS Both plasma hs-CRP and fibrinogen concentrations were reduced(P<0.05) after Simvastatin administration. All parameters of blood flow in the carotid artery were improved significantly(P<0.01).The initial diameter of carotid was significantly enlarged .The size of plaque and IMT were reduced significantly 12 months after Simvastatin therapy(P<0.01). CONCLUSIONS Simvastatin effectively reduced plasma hs-CRP and fibrinogen concentrations in patients with UA, which may improve the stabilization of the plaque in the carotid artery.

关 键 词：辛伐他汀 高敏C反应蛋白 不稳定型心绞痛 动脉粥样硬化 

分 类 号：R972.6[医药卫生—药品]