米利酮和哇巴因的强心效应、安全范围和心脏毒性的比较  

Comparison of positive inotropic effect, safety margin andcardiac toxicity between milrinone and ouabain

作　　者：沙群[1] 沈筱同[1] 

机构地区：[1]上海医科大学药理教研室,上海医科大学附属中山医院,上海市心血管病研究所

出　　处：《中国药理学通报》1994年第1期27-30,共4页Chinese Pharmacological Bulletin

摘　　要：在猫和豚鼠戊巴比妥钠心衰模型上比较了米利酮和哇巴因的强心作用、安全范围和心脏毒性。米利酮作用于衰竭心脏的最大有效量为１２３８±２０３μｇ·ｋｇ－１（猫）、２１０２±２１０μｇ·ｋｇ－１（豚鼠）米利酮安全范围远大于哇巴因。毒性剂量的米利酮发生主要以室性心律失常为主的心电图变化。结果表明，米利酮的强心作用可能无种族差异性，其安全性好．但也会诱发室性心律失常。Positive inotropic effects and safety margin of milrinone had been compared with ouabain on ailing heart model in cats and guinea-pigs.The maximum effective doses of milrinone were 1228±203 μg.kg-1(cats)and 2102±210μg. kg-1(guinea-pigs)respectively.Our data indicated that milrinone was loss toxic than ouahain,its safety margin was wider, and its selectivity was better.No differences of animal species for its inotropic offect had been shown. However the worst possibility was the incidence of cardiac arrhymias in accompany with its positive inotropic and chronotropic effect.

关 键 词：米利酮 哇巴因 强心效应 心脏毒性 

分 类 号：R965.3[医药卫生—药理学]