绞股蓝总皂甙对自由基损伤兔主动脉舒张功能的保护作用  

Protective effect of gypenosides on OFR-induced damage of relaxing capacity of rabbit thoracic aortae in vitro

作　　者：肖观莲 廖端芳[1] 陈剑雄 余麟 

机构地区：[1]衡阳医学院药理教研室

出　　处：《中国药理学通报》1994年第2期136-138,共3页Chinese Pharmacological Bulletin

摘　　要：用离体兔胸主动脉环实验．观察绞股蓝总皂甙（ＧＰｓ）对电解ｋｒｅｂｓ液、黄嘌呤－黄嘌呤氧化酶及美蓝降低血管舒张功能的影响．结果表明ＧＰｓ能保护血管内皮免受自由基损伤。In isolated rabbit thoracic aortae,we investigated the protective effect of gypenosides(GPs) on aortic damage induced by exogenous oxygen free radicals(OFR).The data showed that both electrolysed Krebs solution and xanthine-xanthine oxidase decreased the relaxation of the aortic rings induced by ACh.GPs(50mg·L-1) significantly protected the relaxing capacity of the aortic rings from OFR,so did catalase(25 mg· L-1).The protective effect was abolished by cyclooxgyenase inhibitor indomethacin(5 μmol· L-1).GPs also resisted the decrease of relaxation of the rings induced by methylene blue.

关 键 词：绞股蓝 皂甙 自由基 主动脉 

分 类 号：R282.710.5[医药卫生—中药学]