黄芪对人红细胞膜脂流动性及膜蛋白构象的影响  

Effect of Astragalus on Fluidity of Lipid Regions and Conformation of Protein of Human Erythrocyte Membranes

作　　者：张光平[1] 沈子威[1] 张学贤[2] 

机构地区：[1]清华大学生物科学与技术系生物膜与膜生物工程国家重点实验室,北京100084 [2]中国药科大学物理学教研室,南京210009

出　　处：《中国药科大学学报》1994年第4期238-241,共4页Journal of China Pharmaceutical University

摘　　要：用荧光偏振、圆二色谱(CD)和准弹性光散射等实验技术研究了中药黄芪对人红细胞膜的作用。黄芪能增加人红细胞膜脂流动性,增加膜蛋白中α-螺旋的含量,对膜表面电荷也有影响。黄芪对膜蛋白的作用比对膜脂作用更敏感。黄芪对人红细胞膜作用的一个重要环节可能是保护人红细胞膜免受自由基的攻击。Effect of Astragalus on human erythrocyte membranes (HEM) was studied by fluorescence polarization, circular dichroism (CD) and quasi-elastic light scattering (QELS) techniques. The results showed that Astragalus could increase fluidity of lipid regions and percentage of α-helical protein of HEM, and influence the quantity of charge of membrane surface. The sensitivity of Astragalus on membrane protein was more than that on membrane lipid. An important aspect of the effect probably was that HEM was protected due to decreasing free radical attack.

关 键 词：黄芪 人红细胞膜 膜脂流动性 

分 类 号：R282.710.5[医药卫生—中药学]