萘甲基苯并咪唑衍生物的合成、表征及其杀菌活性  

Synthesis, Crystal Structure and Antimicrobial Activity of Two Novel 2-Naphthalenemethyl Benzimidazole Derivatives

作　　者：王陆瑶[1] 李小娟[1] 陈邦[1] 史真[1] 

机构地区：[1]西北大学化学系,西安710069

出　　处：《应用化学》2005年第6期586-589,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20172041);陕西省自然科学基金(2000H01)资助项目

摘　　要：以1萘乙酸和2萘乙酸为原料,在微波辐射下合成了相应的萘甲基苯并咪唑,经二茂铁磺酰化等步骤,合成了2种未见报道的萘甲基二茂铁磺酰基苯并咪唑衍生物。经元素分析、质谱、核磁共振确证结构。通过X射线衍射,测定了化合物2a的晶体结构。化合物2a为三斜晶系,空间群P1,晶胞参数:a=0.89055(10)nm,b=0.97034(10)nm,c=1.4610(2)nm,α=101.542(2)°,β=95.811(2)°,γ=109.780(10)°,V=1.1443(2)nm3,Z=2,F(000)=526,Mr=507.39,Dc=1.473Mg/m3,μ=1.016mm-1,R1=0.0386,wR2=0.0979。对5种农作物病菌的杀菌活性优于市售50%多菌灵可湿性粉剂。Two novel derivatives of 2-naphthalenemethyl benzimidazole were prepared from the reaction of ferrocenesulfonylchloride with the corresponding 2-naphthalenemethyl benzimidazole. The new compounds were characterized by means of elemental analysis, MS and  1H NMR. The crystal structure of compound 2a was determined by X-ray diffraction. The 2a crystals are triclinic with space group P1, and the unit cell parameters are a= 0.890 55(10) nm, b=0.970 34(10) nm, c=1.461 0(2) nm, α=101.542(2)°, β= 95.811(2)°, γ=109.780(10)°, V=1.144 3(2) nm 3, Z=2, F(000)=526, M_r =507.39, D_c= 1.473 Mg/m3, μ= 1.016 mm -1, R_ 1=0.038 6, wR_ 2 =0.097 9. The antimicrobial activities of the two novel compounds against five fungicides are superior to that of 50% carbendazim wet powder.

关 键 词：萘甲基苯并咪唑衍生物 合成 晶体结构 杀菌活性 

分 类 号：O626.2[理学—有机化学]