一维链状二(3-氟苄基)锡二吡啶羧酸配合物的合成、结构及反应机理  

Synthesis, Crystal Structure and Reaction Mechanism of One-dimensional Organotin Complex [(4-F-H_4CH_2)_2 Sn(3-O_2CC_5H_4N)_2-(4-F-C_6H_4C_2H_5OH)]_n

作　　者：尹汉东[1] 王其宝[1] 薛绳才[1] 朱奇[2] 

机构地区：[1]聊城大学化学化工学院 [2]聊城大学生物系,聊城252059

出　　处：《应用化学》2005年第6期619-623,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20271025);教育部骨干教师基金;山东省自然科学基金(L2003B01)资助项目

摘　　要：利用[(4FC6H4CH2)3Sn]2O与3吡啶甲酸反应,合成了七配位一维链状有机锡配位聚合物[(4FC6H4CH2)2Sn(3O2CC5H4N)2(4FC6H4C2H5OH)]n。通过元素分析、红外光谱和核磁共振氢谱对其结构进行了表征。用X射线单晶衍射测定了化合物的晶体结构,该化合物晶体属单斜晶系,空间群P2(1)/n,a=1.3721(10)nm,b=1.7297(13)nm,c=1.3721(10)nm,β=93.709(8)°,Z=2,V=3.249(4)nm3,Dc=1.505g/cm3,μ=1.695mm-1,F(000)=1480,R=0.0480,wR=0.0978。结果表明,该化合物中锡原子配位数为7,处在畸变五角双锥配位场中,化合物通过吡啶基氮原子的桥连作用形成了一维无限链状结构。生物活性测试结果表明,该化合物对MCF7和WiDr均表现出较好的抑制作用,其ID50值分别为1.56×10-7和1.89×10-7g/mL。A novel hepta-coordinated organotin complex \[(4-F-C_ 6H_ 4CH_ 2)_ 2Sn(3-O_ 2CC_ 5H_ 4N)_ 2(4-F-C_ 6H_ 4- C_ 2H_5OH)\]_ n was synthesized from the reaction of \[(4-F-C_ 6H_ 4CH_ 2)_ 3Sn\]_ 2O with 3-pyridinecarboxylic acid and characterized by means of elementary analysis, IR and  1H NMR. The crystal structure was determined by single crystal X-ray diffraction study. The crystal belongs to the monoclinic system with space group P2(1)/c, a=1.763 4(12) nm, b=1.277 6(9) nm, c=1.360 6(9) nm, β=96.991(11)°, Z=4, V= 3.043(4) nm3, D_ c=1.575 g/cm 3, μ=0.904 mm -1, F(000)=1 456, R_ 1=0.040 5, wR_ 2=0.068 2. In the complex, the tin atom is hepta-coordinated in a distorted pentagonal bipyramid including a bridging pyridyl N atom, by which the one-dimensional infinite chain is formed. The antitumor activity tests for the human tumor cell lines MCF-7 and WiDr show that this complex exhibits a good bioactivity.

关 键 词：有机锡配合物 吡啶甲酸 合成 晶体结构 生物活性 反应机理 

分 类 号：O641[理学—物理化学]