聚(D,L)-乳酸的合成及生理盐水降解性  

Synthesis of Poly(D,L-Lactic Acid) and Its Degradation in Saline Solution

作　　者：王华林[1] 方大庆[1] 史铁钧[1] 翟林峰[1] 王继植[1] 

机构地区：[1]合肥工业大学化工学院

出　　处：《应用化学》2005年第6期657-660,共4页Chinese Journal of Applied Chemistry

基　　金：安徽省自然科学基金资助项目(01044803)

摘　　要：在催化剂辛酸亚锡(ZnOct2)的作用下,合成了聚D,L乳酸(PDLLA)。研究了催化剂用量、反应温度和时间对PDLLA分子量的影响。得到的最佳合成条件为:ZnOct2质量分数为0.5%,聚合温度为170℃,聚合时间为7h。考察了PDLLA在生理盐水中的降解情况,采用XRD对降解产物进行了表征。结果表明,PDLLA降解时,先生成不溶于生理盐水的低聚物,然后生成可溶性的低聚物,并有(D,L)丙交酯形成,质量损失迅速增加,最终降解完全。Using stannous octoate (ZnOct_ 2) as the catalyst, poly (D,L-lactic acid)(PDLLA) was synthesized. The effects of catalyst amount, polymerization temperature and time on the molecular weight of PDLLA were studied. The optimal conditions were as follows: mass fraction of ZnOct_ 2 0.5%, reaction temperature 170 ℃, reaction time 7 h. The degradation of PDLLA in normal saline was explored, and the degradation products were characterized by XRD. The results showed that during the degradation process, insoluble oligomers were produced first, and then soluble oligomers and D,L-lactide were produced, and the material lost mass rapidly, and finally PDLLA degraded completely.

关 键 词：聚(D L)-乳酸 D L-丙交酯 生理盐水 降解性 

分 类 号：O633[理学—高分子化学] R318.0[理学—化学]