大鼠海马内强啡肽_(1-8)和亮啡肽在癫痫发作及电针时的变化  

Alteration of dynorphin 1-8 and leu-enkephalin in rat hippocampus during seizure and electroacupuncture

作　　者：王布尔[1] 程介士[1] 

机构地区：[1]上海医科大学神经生物学教研室

出　　处：《中国药理学报》1994年第2期155-157,共3页Acta Pharmacologica Sinica

基　　金：Project supported by the National Natural Science Foundation of China;№ 39170897.

摘　　要：用免疫组织化学方法观察大鼠青霉素致痛及加电针后脑内强啡肽。及亮啡肽的变化。致痫时,在海马门区及苔样纤维上强啡肽含量明显减少,在海马下脚、CA_1区等结构内亮啡肽含量明显增加,电针后海马中强啡肽含量增加,亮啡肽含量在上述各区显著减少。提示:癫痫及电针抗痫可能与脑内强啡肽和亮啡肽的变化有关。Immunocytochemical technics were used to evaluate the influence of penicillin-induced seizure and electroacupuncture treatment on dynorphin1-8 and leu-enkephalin immunoreactivity in hippocampus. It was found that 3 h after beginning of seizure there started a dramatic decrease in dynorphin1-8 in hilus, mossy fiber of hippocampus but an increase in hilus, mossy fiber of hippocampus but an increase in leu-enkephalin in subicu-lum, CA1 area of hippocampus and some other limbic structures. Electroacupuncture treatment decreased the leu-enkephalin immunoreactivity in the nuclei mentioned above and increased dynorphin1-8 immunoreactivity in hippocampus. The results show that epilepti-form activity and electroacupuncture inhibitory effect on seizure may be related to the alteration of dynorphin1-8 and leu-enkephalin in the brain.

关 键 词：强啡肽 亮啡肽 海马 电针 免疫组化 

分 类 号：R965.2[医药卫生—药理学]