3,15-二乙酰苯甲酰乌头原碱镇痛的作用部位  

Sites of analgesic action of 3,15-diacetylbenzoylaconine

作　　者：张慧灵[1] 杨煜荣[2] 王勇[2] 郑平[3] 王洪诚[4] 劳爱娜[4] 

机构地区：[1]Graduate student [2]包头医学院药理教研室 [3]Department of Pharmacology, Shanghai Medical University, Shanghai 200032 China. [4]中国科学院上海药物研究所

出　　处：《中国药理学报》1994年第2期176-180,共5页Acta Pharmacologica Sinica

基　　金：Project supported by the National Natural Science Foundation of China.№ 39260076.

摘　　要：用大、小鼠四种测痛方法证实,ip DABA具有剂量依赖性镇痛作用ith DABA (527,1186 μR·kg^(-1)不产生镇痛作用;icv (35—75μS·kg^(-1)及水管周灰质注射DABA(20μg)均呈显著镇痛作用;损毁双侧蓝斑,DABA镇痛作用消失;蓝斑处注射DABA(20μg)不产生镇痛作用,揭示DABA的镇痛作用部位主要在中枢脊髓以上结构,水管周灰质是DABA镇痛的原发作用部位之一,蓝斑是其作用的中间环节之一。In the rat hot plate test, vocalization induced by electric stimulation, tail flick test, and the mouse acetic acid writhing test. 3, 15-diacetylbenzoylaconine (DABA) ip exhibited a dose-dependent analgesic activity. Intrathecally (ith) administered DABA (527, 1186 μg·kg-1) had no analgesic action. Mi-croinjection of DABA 35 - 75 μg·kg-1 or 20 μg into the cerebral ventricle (icv) or the peri-aqueductal gray (PAG) exerted a remarkable analgesic activity, which was abolished after bilateral lesions of locus coeruleus (LC). Mi-croinjection of DABA (20 μg) into LC failed to produce apparent analgesic action . These results suggested that the sites of analgesia of DABA were mainly at the central supraspinal structures, and PAG was one of the primary sites, while LC was one of the intermediate links.

关 键 词：乌头碱 镇痛 脊髓 水管周灰质 蓝斑 

分 类 号：R971.1[医药卫生—药品]