氯丙嗪对小鼠肠道活动的抑制作用及其拮抗药  

Inhibitory action of chlorpromazine on intestinal movement in mice and its antagonistic agents

作　　者：熊玉卿[1] 李宝华[1] 

机构地区：[1]江西医学院药理教研室

出　　处：《中国药理学报》1994年第3期235-239,共5页Acta Pharmacologica Sinica

摘　　要：Chl和Sco ip或icv均可抑制排便和肠道转运功能。Chl和Sco iv抑制排便的ED_(50)分别是0.85和3.49mg·kg^(-1),Sco的作用可被Phy(0.08 mg·kg^(-1),sc)拮抗,不被icv Pil(100—200μg)和4-AP(1μg)拮抗,而ChL的作用不被Phy(0.08mg·kg^(-1))拮抗,可被icvCil(100μg)和4-AP(1μg)拮抗。这提示Chl抑制小鼠肠道运动是抑制中枢释放ACh所致,Neo和Car也可拮抗Chl抑制排便。r Adynamic ileus is a toxic effect produced by chlorpro'mazine (Ch1). The present study is to analyze the inhibitory action of Ch1 on the intestinal movement of mice and to search its antagonistic remedies. Inhibition was evaluated by 2 tests : the loss of defecation reflex and the inhibited transport of phenol red in the intestinal tract. Ch1 (1 - 2 mg ·kg-1 ip or 1 μg per mouse icv) inhibited the intestinal movement powerfully. Scopol-amine (Sco 4 mg · kg-1 ip or 4 - 8 μg per mouce icv) produced the same effect. The iv ED50(L85) of Ch1 and Sco for inhibition of the defecation reflex were 0. 85 (0. 79-0. 93) and 3.49 (3.24-3.78) mg·kg-1, respectively. Haloperidol (1 - 4 mg ·kg-1 ip) , sulpiride (10 mg ·kg-1 ip), and phentolamine (2-4 mg ·kg-1 ip or 4 μg per mouse icv) did not affect the defecation reflex. In the isolated guinea pig ileum the pA2 value of Ch1 against carba-chol (Car) was 4. 5 and that of Sco was 9.1. In addition, the inhibitory effect caused by Sco was antagonized by physostigmine (Phy 0. 08 mg·kg-1 sc), but not by pilocarpine (Pil 100 - 200 μg per mouse icv) and 4-aminopyri-dine (4-AP 1 μg per mouse icv), whereas that caused by Ch1 was antagonized by Pil (100 μg per mouse icv) and 4-AP (1 μg per mouse icv), but not by Phy- Neostigmine (Neo 0. 05 mg ·kg-1 sc) or Car (0. 05 mg ·kg-1 sc) combined with 4-AP (2 mg·kg-1 sc) exhibited a synergetic effect against Ch1-induced inhibition. The results suggested that the inhibitory effect of Gh1 on the intestinal movement was produced by preventing the release of acetylcholine from the central nervous system.

关 键 词：氯丙嗪 东莨菪碱 联合药物疗法 

分 类 号：R965.2[医药卫生—药理学]