己酮可可碱减轻血小板激活因子致离体豚鼠肺通透性水肿(英文)  

Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs

作　　者：李少华[1] 费侠 陈思锋[1] 丁自强[1] 吴中立[1] 

机构地区：[1]第二军医大学病理生理学教研室

出　　处：《中国药理学报》1994年第3期219-222,共4页Acta Pharmacologica Sinica

基　　金：Projects supported by the National Natural Science Foundation of China № 3880399 and № 39270780.

摘　　要：血小板激活因子(PAF,1 nmol·L^(-1))可使离体灌注豚鼠肺重量和微血管液体滤过系数明显增加,已酮可可碱(Pen,0.5和1.0mmol·L^(-1))对此有明显抑制作用,但对PAF引起的肺毛细血管压和静脉阻力的增高无明显影响。各组动物肺水肿的程度与灌注液中白细胞数无相关关系,提示Pen有直接抗肺血管通透性的作用。The effect of pentoxifylline (Pen) on platelet activating factor (PAF)-in-duced pulmonary injury was studied in isolated guinea pig lungs perfused with cell-free Tris buffered Ringer solution. PAF (1.0 nmol ·L-1) increased lung weight and pulmonary filtration coefficient (Kf) , which indicated the formation of high permeable pulmonary edema. Pen (0. 5 and 1. 0 mmol·L-1) markedly attenuated the PAF-induced increment of lung weight and vascular permeability, but not the increment of pulmonary capillary pressure and venous resistance. There was no correlation between the severity of lung edema and the number of leukocytes in the perfusates. These results suggest that Pen has direct anti-permeability effect on pulmonary microvessels.

关 键 词：己酮可可碱 肺水肿 血小板 

分 类 号：R965.2[医药卫生—药理学]