苦参碱对大鼠输精管的作用与激活钙通道的关系  

Relation of effects of matrine on rat vasa deferens to activation of calcium channels

作　　者：王桂林[1] 张莎莎[1] 李志红[1] 刘世芳 

机构地区：[1]内蒙古医学院药理教研室

出　　处：《中国药理学报》1994年第3期279-281,共3页Acta Pharmacologica Sinica

摘　　要：哌唑嗪(10 μmol·L^(-1)),硝苯地平(50nmol·L^(-1))可竞争性拮抗苦参碱收缩大鼠离体输精管,pA_2值分别为5.1和9.29,维拉帕米(1 μmol·L^(-1))可非竞争性拮抗苦参碱,pD_2为6.07。苦参碱可增强CaCl_2和KCl收缩输精管的作用,对KCI的增强作用更显著,提示苦参碱是一钙通道激动剂。Effective mechanisms of matrine (Mat) in contraction were observed in isolated rat vasa deferens. Mat caused a strong concentration-dependent contraction of vasa deferens, and this contraction was competitively inhibited by prazosin (Pra , 10 μmol·L-1) and nifedipine (Nif, 50 nmol·L-1), with depression of maximal responses. Their pA2 value was 5.1 and 9.29, respectively. The contraction was also inhibited by verapamil (Ver, 1 μmol·L-1) with depression of maximal responses ; but this antagonism was noncompeti-tive. Its pD 2 value was 6. 07. Mat promoted CaCl2-induced contraction of vas deferens. The effect of Mat was enhanced in proportion to increase in concentrations of CaCl2. Mat markedly strengthened KC1-induced contraction of I'as deferens. The results suggest that one of the mechanisms of the contractive effects of Mat within a certain range of concentrations was related to the activation of the calcium channel.

关 键 词：苦参碱 输精管 哌唑嗪 维拉帕米 

分 类 号：R965.2[医药卫生—药理学]