去上皮对离体气管平滑肌反应性的影响(英文)  

Influence of epithelium removal on allergic contraction of isolated tracheal smooth muscle

作　　者：李锦[1] 张海娟[1] 靳素珍 杨贺松[1] 

机构地区：[1]承德医学院药理教研室

出　　处：《中国药理学报》1994年第4期344-346,共3页Acta Pharmacologica Sinica

摘　　要：去上皮致敏豚鼠气管标本对乙酰胆碱。组胺,P物质和氯化钡的敏感性比未去上皮标本为高。上述药物在去上皮标本上得到的EC_(50)仅为未去上皮的1/6—1/30。由抗原抗体反应或电场刺激所引起的去上皮标本的收缩幅度和对照组相比升高了50％—100％。这些实验结果提示,气管上皮对呼吸道,尤其是对其过敏性收缩具有重要调节作用。Sensitized guinea pig tracheal preparations with epithelium removed were more sensitive To acetylcholine, histamine substance P, and barium chloride than those with epithelium intact. EC50 of them obtained in the preparations with epithelium removed dramatically decreased to 1/6-1/30 vs that obtained in epithelium intact ones. The amplitudes of contractions of epithelium-removed preparations induced by antigen-antibody reaction or electric field stimulation increased by 50) %-100% vs the control. These results indicated that the epithelium had important modulative effects on the airway, especially on its allergic contractions.

关 键 词：乙酰胆碱 组胺 P物质 气管 上皮 

分 类 号：R965.2[医药卫生—药理学]