间尼索地平对麻醉大鼠动脉压力感受性反射敏感性的影响  

Effects of m-nisoldipine on arterial baroreflex sensitivity in anesthetized rats

作　　者：张雅兰[1] 傅绍萱[1] 李蕴山[1] 

机构地区：[1]河北医学院药理教研室

出　　处：《中国药理学报》1994年第5期466-469,共4页Acta Pharmacologica Sinica

摘　　要：本文用苯福林或硝普钠iv于麻醉大鼠,引起BP最大变化(ΔBP)所致反射性HR最大变化(ΔR-R)的回归直线斜率为动脉压力感受性反射敏感性(BRS)的指标,测得iv m-Nis 5,10,20μg·kg^(-1)均明显降低BRS(P<0.01),m-Nis抑制BRS可能是直接作用于颈动脉窦压力感受器。Baroreflex sensitivity (BRS) in anesthetized rats was measured as the slope of the regression line of the concomitant maximal change in heart rate (AR-R) and blood pressure (ABP) induced by bolus iv phenylephrine or sodium nitroprusside. m-nisoldipine (m-Nis) iv 5, 10, 20 μg · kg-1 depressed the BRS (2.6 ± 0.2, 2.4 ± 0.3, 1.6 ± 0.2, or 1.7 ± 0. 1, 1.6 ± 0.2, and 1. 4 ± 0. 2 ms · kPa-1, respectively ) compared with before medication (P < 0.01). m-Nis may act directly on carotid sinus to depress the BRS, but not through cardiac β or M receptor nor through central nervous system.

关 键 词：间-尼索地平 血压 心率 硝普盐 

分 类 号：R965.2[医药卫生—药理学]