腺苷对小鼠非特异免疫和体液免疫的抑制作用  

Suppressive effects of adenosine on nonspecif- ic and humoral immunities in mice

作　　者：冯(龙天)熙 刘发[1] 边棣 胡坚[1] 

机构地区：[1]新疆医学院药理教研室

出　　处：《中国药理学报》1994年第5期473-476,共4页Acta Pharmacologica Sinica

摘　　要：腺苷(adenosine,Ade)1.3,13,130mg·kg^(-1)抑制小鼠全血白细胞和腹腔巨噬细胞的吞噬功能;减少小鼠血清溶菌酶的含量;降低小鼠血清溶血素的生成和空斑形成细胞的溶血能力。双嘧达莫10mg·kg^(-1)减弱Ade 130mg·kg^(-1)的体液免疫抑制作用;氨茶碱100mg·kg^(-1)可减弱Ade 130mg·kg^(-1)对脾空斑形成细胞溶血能力和外周血白细胞吞噬功能的抑制作用。Adenosine (Ade) 1.3, 13, ,130 mg·kg -1 ip inhibited the ability of peripheral leukocytes and peritoneal macrophages in phagocytosing the Staphylococcus albus with [3H]TdR incorporation in mice,declined the hemolytic ability of plaque-forming cells and the production of antibody in mice immunized by sheep erythrocytes. Ade 13, 130 mg·kg-1 ip decreased the mouse serum muramidase ( lysozyme ) concentration. Dipyridamole (Dip) 10 mg·kg-1 ip attenuated the effects of Ade 130 mg·kg-1 on humoral immunity reaction , but the nonspecific immunity was not attenuated. These results showed that the uptake of Ade may play an important role in the effects of Ade on humoral immunity reaction. Aminophylline (Ami) 100 mg·kg-1 ip attenuated the effects of Ade 130 mg · kg-1 on hemolytic ability of plaque-forming cells and the ability of peripheral leukocytes in phagocytosing Staphylococcus albus. These results suggested that the effects of Ade on murine humoral and nonspecific immunity reaction were mediated by Ade A2 receptor (A2DR).

关 键 词：腺苷 吞噬作用 溶菌酶类 双嘧达莫 

分 类 号：R965.2[医药卫生—药理学]