卡托普利和可乐定对自发性高血压大鼠左心室静息及负荷功能的影响(英文)  

Effects of captopril and clonidine on resting and stress cardiac perfor- mance of left ventricle in spontaneously hypertensive rats

作　　者：晋学庆[1] 陈达光[1] 张声[1] 王华军[1] 

机构地区：[1]福建医学院附属第一医院高血压研究室

出　　处：《中国药理学报》1994年第6期501-506,共6页Acta Pharmacologica Sinica

基　　金：National Natural Science Foundation of China.№ 3880409;Presented at the Beijing International Conference on Heart Research 1992 May 16-17;Asian-Pacific Symposium on ACE Inhibition.Hong Kong 1993 Feb 17-20.

摘　　要：卡托普利(Cap)和可乐定(Clo)极早期治疗SHR大鼠,观察BP,LVM/BW,压力反射敏感性,静息心脏功能及前后负荷增加时ΔLVdp/dt_(max)的变化。Cap,Clo均明显防止SHR大鼠BP的升高。Cap不仅降低LVM/BW,且明显改善静息及前后负荷增加时左室收缩与舒张功能。同时Cap明显增加压力反射敏感性。而Clo则无此作用。且可能左室肥厚与压力反射敏感性有关。Captopril (Cap) 20 mg·kg-1 ·d-1 and clonidine (Clo) 300 μg·kg-1·d-1 were given po to SHR from their parents mating day to 24 wk of age, with untreated, age-matched SHR and WKY as controls. Stress cardiac function was assessed by the development of LVdp/dtmax in response to incremental pressure load (phenylephrine, Phe) and volume load (dextran, Dex). The slope of AHR/AMAP relationship curve was used as an index of baroceptor sensitivity. Results showed that both Cap and Clo caused decreases in BP in SHR. Cap not only reduced markedly the left ventricular mass/body weight (LVM/BW), .(mg·g -1, 2. 7 ± 0. 4 vs SHR 3.5 ± 0.3, P<0. 01), but also normalized the LVdp/dp/dtmax,- LVdp/dtmax,T value, and the stress cardiac function. Clo neither decreased the LVM/BW (mg·g-1, 3. 4±0. 5 vs SHR 3. 5 ±0.3, P>0. 05), nor improved the resting and stress cardiac function. The results suggested that attenuation of the left ventricular hypertrophy (LVH) is beneficial not only to the resting but also stress cardiac performance.

关 键 词：卡托普利 可乐定 心脏功能试验 苯福林 大鼠 

分 类 号：R965.2[医药卫生—药理学]