3’-当归酰氧基-4’-乙酰氧基-3’,4’-双氢邪蒿内酯对麻醉犬心脏血流动力学的影响(英文)  

Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on cardiohemodynamics in anesthetized dogs

作　　者：常天辉[1] 足立秀之[1] 奥山徹 森信行 斋藤勋 张克义[1] 孙晓东[1] 李金鸣[1] 

机构地区：[1]中国医科大学药理教研室

出　　处：《中国药理学报》1994年第6期507-510,共4页Acta Pharmacologica Sinica

摘　　要：本文研究了3’-当归酰氧基-4’-乙酰氧基-3’,4’-双氢邪蒿内酯(Pd-Ia)和地尔硫(艹卓)(Dil)对麻醉犬心脏血流动力学的影响。Pd-Ia剂量依赖性增加冠流量,减少主动脉压(MAP),+dp/dt_(max),率压积(RPP)及全身血管阻力,并加快HR。Dil与Pd-Ia作用相似,但明显减慢HR。Pd-Ia对MAP及RPP的作用约为Dil的1/10。结果再次表明:Pd-Ia是一Ca^(2+)通道阻滞剂。Cardiohemodynamic effects of 3'-angeloyloxy-4'-acetoxy-3', 4'-dihydroseselin (Pd-Ia) isolated from the Chinese medicinal plant Peucedanum praeruptorum Dunn were compared with those of diltiazem (Dil) in anesthetized open-chest dogs. Pd-Ia 3 mg ·kg -1 increased coronary blood flow from 25± 11 to 58±16 ml·min-1(n = 7, P<0. 01) and decreased mean aortic pressure (MAP) from 13±2 to 8±1 kPa (P<0. 01), rate pressure product (RPP) from 1.9 ±0.5 to 1.3 ±0.3 MPa·bpm (P<0. 05), ±dp/dtmax from 246± 56 to 160±36 kPa·s-1(P<0. 01) and systemic vascular resistance from 19±4 to 12±7 Pa·ml-1 ·min-1(P<0. 05), together with an increase in HR: Dil showed effects similar to those of Pd-Ia except for a marked decrease in HR. The effects of Pd-Ia on MAP and RPP were approximately one-tenth as potent as those of Dil. The results demonstrated that Pd-Ia was a Ca2+ channel blocker.

关 键 词：香豆素 钙拮抗剂 地尔硫卓 血液动力学 

分 类 号：R971.2[医药卫生—药品]