阿斯匹林、奥昔麻黄碱及两者并用对血小板聚集和血栓形成的影响  

Effects of the combination of Aspirin and Oxyfedrine on platelet aggregation and thrombogenesis

作　　者：赵晓梅[1] 厚华钢[1] 杨玉梅[1] 石山[1] 

机构地区：[1]包头医学院心血管研究室

出　　处：《中国药理学通报》1994年第3期211-213,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金

摘　　要：阿斯匹林与奥昔麻黄碱均抑制ＡＤＰ诱导的大鼠体内血小板聚集和实验性脑血栓形成．滞后电刺激大鼠颈动脉血栓形成时间．减少肾上腺素和胶原复合诱导剂静注所致小鼠肺血栓造成的死亡．剂量与效应相关．两者合用作用增强．The effects of Aspirin(ASA),Oxyfedrine(OXY)and ASA+OXY on plateletaggregation and generation of thrombosis werestudied.ASA and OXY respectively inhibitedplatelet aggregation in vivo induced by ADP andexperimenta cerebral thrombosis,and postPonedthe time of thrombosis induced by eletrical stimulation of the carotid artery in rate,also reducedthe death rate resulted from pulmonary thrombosis induced by inducer composed of collagen andepinephrine(iv)in mice.The effects Of combination of ASA and OXY markedly increased.Meanwhile,all of those effects showed good dose-dependent manner.

关 键 词：阿斯匹林 奥昔麻黄碱 血小板聚集 

分 类 号：R969.2[医药卫生—药理学]