尼群地平对糖尿病大鼠心肌收缩功能和呼吸酶活性的影响  

Effects of nitrendipine on myocardial contractility and respiratory enzyme activities in diabetic rats

作　　者：李才[1] 刘松岩[1] 王丽娟[1] 侯芳玉[1] 战术[1] 刘伟[1] 孙淑艳[1] 

机构地区：[1]白求恩医科大学应用基础医学研究所,白求恩医科大学基础医学院,白求恩医科大学第一临床学院

出　　处：《中国药理学通报》1994年第3期190-193,共4页Chinese Pharmacological Bulletin

基　　金：吉林省科委资助课题

摘　　要：研究尼群地平（Ｎｉｔ）对实验性糖尿病大鼠心肌舒缩功能、心肌琥珀酸脱氢酶（ＳＤＨ）和细胞色素氧化酶（ＣＣＯ）活性及血脂水平的影响。结果表明，诱发糖尿病８Ｗｋ的大鼠心室舒张和收缩功能均明显受损。口服Ｎｉｔ３０ｍｇ·ｋｇ－１可改善糖尿病大鼠心室舒张和收缩性能。糖尿病大鼠心肌ＳＤＨ和ＣＣＯ活性较对照大鼠明显下降，糖尿病大鼠接受Ｎｉｔ３０ｍｇ·ｋｇ－１．ｐｏ．可显著恢复这些酶的活性。Ｎｉｔ处理对糖尿病大鼠血清总胆固醇、甘油三酯和β脂蛋白含量无明显影响。研究结果提示．Ｎｉｔ处理对大鼠糖尿病性心肌病心肌功能的恢复是有益的。In the present study, we investigated the effects of nitrendipine(Nit)on myocardial contractility,myocardial succinate dehydrogenase(SHD),cytochrome oxidase(CCO)activities and blood lipid content in diabetic rats made by an injection of streptozotocin ( 65 mg· kg-1).The results showed that both ventricular diastolic and systolic functions were obviously injured in rats 8 wk after induced diabetes. These changes were sighsficantly impraed in diabe tie but were improved after receiving Nit(30 mg·kg-1)treatment.The myocardial SDH and CCO activities in diabetic animals were markedy lower than those of controls.The attenuation of these enzyme activities in diabetic rats was significantly reversed by administration of Nit.The levels of serum total cholesterol,triglyceride and β-lipoprotein were not markedly affected in Nit- treated diabetic rats. These findings suggest that Nit treatment may exhibit some beneficial effects on diabetic cardiomyopathy.

关 键 词：尼群地平 糖尿病 心肌收缩功能 

分 类 号：R587.105[医药卫生—内分泌]