阿托品对6种血管活性物质收缩犬离体脾动脉作用的影响  

Effects of atropine on vasoconstriction induced by six vasoactive substances observed in the canine isolated splenic artery

作　　者：吴敬敏[1] 杨小平[1] 

机构地区：[1]河北医学院微生物教研室,河北医学院药理教研室

出　　处：《中国药理学通报》1994年第4期305-308,共4页Chinese Pharmacological Bulletin

摘　　要：应用血管插管法观察了阿托品１μｍｏｌ·Ｌ－１对数种血管收缩物质作用的影响。去甲肾上腺素、去氧肾上腺素、５－羟色胺、组织胺、三磷酸腺苷（ＡＴＰ）及氯化钾（ＫＣｌ）可以收缩犬离体脾动脉标本，它们的收缩血管作用呈量效关系。应用１μｍｏｌ·Ｌ－１阿托品灌流脾动脉标本时，５－羟色胺、ＡＴＰ及ＫＣｌ的缩血管效应无显著变化，但是去甲肾上腺素、去氧肾上腺素及组织胺的收缩血管活性显著降低。以上结果表明，在犬离体脾动脉标本，１μｍｏｌ·Ｌ－１浓度阿托品具有抑制α肾上腺素受体激动剂及组织胺的收缩血管作用。Effects of 1μmol·L-1 atropine on the vasoconstricitive responses to noradrenaline,phenylephrine,5-hydroxytryptamine, histamine, adenosine triphosphate(ATP) and KCl were observed in the canine isolated splenic artery, using the cannula insertion method. Six vasoactive agents induced the vasoconstrictive responses in a dose-dependent manner. Atropine perfusion at 1μmol·L-1 inhibited the vascular responses to noradrenaline, phenylephrineand histamine significantly,but it did not significantly affect the vasoconstrictive responses to 5-hydroxytryptamine, ATP and KCl in the splenic artery. We conclude that 1μmol·L-1 atropine has an inhibitory effect on α-adrenoceptor agonists-or histamine-induced vasoconstriction in the canine splenic artery.

关 键 词：阿托品 血管活性物质 血管 药理 

分 类 号：R966[医药卫生—药理学]