3，6—（二甲氨基）—二苯并碘杂六环柠檬酸盐保护大鼠缺血再灌注心肌与抗脂质过氧化的关系  

Correlation between cardioprotection of 3,6-dimethamidodibenzopyriodoniumcitrate against ischemia and reperfusion damage and inhibition of myocardial lipid peroxidation in rats

作　　者：邓秀玲[1] 邱培伦[1] 边晓丽[1] 王美纳[1] 陈淑英[1] 侯自杰[1] 

机构地区：[1]西安医科大学药理教研室,兰州大学化学系

出　　处：《中国药理学与毒理学杂志》1994年第1期40-42,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金

摘　　要：在大鼠在体心肌缺血再灌注模型上，观察了３、６（二甲氨基）二笨并碘杂六环柠檬酸盐（１６５）的抗心肌缺血再灌注损伤及抗脂质过氧化作用结果表明１－６５能明显改善缺血再灌注所致的心肌光镜及电镜下细胞结构损伤，升高心肌超氧化物歧化酶和谷胱甘肽过氧化物酶活性，减少丙二醛生成提示Ｉ６５对心肌缺血再灌注损伤的保护作用与保护氧自由基清除酶的活性．The correlation between the protec-tion of 3,6- dimethamidodibenzopyriodonium citrate(I-65) against myocardial ischemia and reperfusiondamage and the inhibition of oxygen free radicals andlipid peroxidation was observed with rat hearts in vivo.Pretreatment of I- 65(0.5 mg· kg)significantly pro-tected the microstructure and ultrastructure fromreperfusion injury,the myocardial superoxidedismutase and glutathione peroxidase activities were in-creased and the malondialdchvdecontent was reducedThe results indicate that the benencial effects of I-65on myocardial isehemia and reperfusion injury are probably derived from its protection of the activity ofthe free radical scavenger enzymes and the preventionof lipid peroxidation to membranes.

关 键 词：碘Weng化合物 心肌缺血 再灌注损伤 

分 类 号：R965.1[医药卫生—药理学]