甘露醇和苯甲酸钠对阿霉素毒性和抗肿瘤活性的影响  

Effects of mannitol and sodium benzoate on the toxicity and antitumor activity of doxorubicin

作　　者：曹兆丰[1] 张尚明[1] 王秋菊[1] 罗玲[1] 户万秘[1] 崔学增[1] 

机构地区：[1]华北煤炭医学院免疫病理及细胞毒理研究室

出　　处：《中国药理学与毒理学杂志》1994年第3期237-238,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：甘露醇和苯甲酸钠对阿霉素毒性和抗肿瘤活性的影响曹兆丰，张尚明，王秋菊，罗玲，户万秘，崔学增（华北煤炭医学院免疫病理及细胞毒理研究室，唐山０６３０００）阿霉素（ｄｏｘｏｒｕｂｉｃｉｎ，Ｄｏｘ）作为多种恶性肿瘤的主要化疗药物已得到广泛应用，但由于其对心脏...The effects of mannitol and sodiumbenzoate on the toxicity and antitumor activity ofdoxorubicin (Dox) were investigated.Rat hvermitochondria were incubated with Dox and the inhibi-tion of the cytochrome C oxidase activity by Dox wasmeasured.The cytochrome C oxidase activity wasstrongly depressed (42.1%,P<0.001)by Dox,whereasthis activity was well restored in mannitol or sodiumbenzoate. It was also found that Doxinducedinhibition of[3H]TdR incorporation into DNA ofHRT- 18 cells in vitro was not affected by mannitol orsodium benzoate.The protection of mannitol orsodium benzoate against the mitochondria toxicity ofDox appears no interference with the antitumoractivity of Dox.

关 键 词：甘露醇 苯甲酸钠 阿霉素 毒性 

分 类 号：R979.1[医药卫生—药品]