13α─羟基苦参碱的抗腹泻和抗炎作用  

Antidiarrheal and anti-inflammatory effects of 13α─hydroxymatrine

作　　者：沈雅琴[1] 张明发[1] 

机构地区：[1]陕西省中医药研究院药理研究室

出　　处：《中国药理学与毒理学杂志》1994年第3期206-208,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：小鼠ｉｇ１３α─羟基苦参碱（ＨＭ）明显减少乙酸引起的扭体反应次数［ＥＤ５０及９５％可信限（ＣＬ）为２３５±ＣＬ４７ｍｇ·ｋｇ－１）］，ｓｃ９０和１８０ｍｇ·ｋｇ－１显著抑制乙酸增加小鼠腹腔毛细血管通透性和二甲苯引起的小鼠耳壳肿胀，ｉｇ１８０和３６０ｍｇ·ｋｇ－１可抑制组胺引起大鼠皮肤毛细血管通透性增高。拮抗蓖麻油和番泻叶引起的小鼠腹泻。也能抑制小鼠胃肠墨汁推进运动推测ＨＭ的止泻机理可能是抗炎和抑制胃肠推进运动。ＨＭ对小鼠的ｉｇ和ｉｐＬＤ５０分别为１．７７±ＣＬ０．１７ｇ·ｋｇ－１和５１７±ＣＬ４１ｍｇ·ｋｇ－１．α─Hydroxymatrine(HM)decreased the writing frequency induced by ip0.7% aeetic acid in mice,ED50 and 95 % confidence limits(CL)was 235± CL 47 mg·kg-1(ig).HM 90 and 180mg·kg-1 sc inhibited the increased vascular permeability induced by ip 0.7%acetic acid and xylene-induced swelling of mouse ear.HM 180 and 360 mg·kg-1 ig inhibited the increased vascularpermeability induced by ic histamine in rats.The anti-inflammatory effects were enhanced in a dose-de-pendent manner,HM 180 and 360 mg·kg-1 ig reduced the purgative effects of castor oil and senna in mice,and the gastrointestinal transport of Chinese ink in normal mice.It is suggested that the antidiarrheal ef-fect of H M is relative to its restriction against exudative inflammation and the gastrointestinal trans-port function. LD50 of HM ig and ip in mice were 1.77±CL 0.17 g·kg-1 and 517± CL 41 mg·kg-1 respectively.

关 键 词：羟基苦参碱 止泻药 抗炎剂 

分 类 号：R975.3[医药卫生—药品]