白芍总甙和丹皮总甙对松果腺调节炎症免疫反应的影响  

Effects of total glucosides of paeony and moutan cortex on the fonctions of pineal gland in inflammatory-immune regulation in rats

作　　者：徐叔云[1] 沈玉先[1] 许杜娟[1] 魏伟[1] 梁君山[1] 

机构地区：[1]安徽医科大学临床药理研究所

出　　处：《中国药理学与毒理学杂志》1994年第3期161-165,共5页Chinese Journal of Pharmacology and Toxicology

摘　　要：本文采用普萘洛尔（１５ｍｇ·ｋｇ－１·ｄ－１×７ｄｉｐ），双侧颈上神经节切除以及松果腺切除法观察了白芍总甙（ＴＧＰ）和丹皮总甙（ＴＧＭ）对松果腺调节炎症，免疫反应的影响。Effects of total glucosides of paeonytTGP) and total glucosides of moutan cortex (TGM)on the function of pineal gland in inflammatoryimmunoregulation in rats were studied by means ofindirect pinealectomy [propranolol (Pro),superiorcervical ganghonectomy [SCGX)] and directpinealectomy (PX).In normal rats,concanavalin A(Con Aj and hpopolysaccharide (LPS)-inducedproliferation of lymphocytes and Con Ainducedinterleukin 2 (IL2) production of splenocytes were inhibited by Pro and SCGX respectively. Con A andLPSinduced proliferation of splenocytes wassignificantly suppressed by PX in both normal andadluvant arthntis (AA) rats.PX of normal rats coulddecrease IL-1 production which was increased furtherin PX AA rats.Melatonin (10μg·kg-1·d-1 ip), TGP(50 mg·kg-1·d -1 ig).and TGM(10 mg·kg-1·d -1.ig)administrated once a day at 1600 could antagonizethe immune changes caused by PX.These suggestthat melatonin is an important inflammatoryiminunoregulatory agent. the effects of TGP and TGMon inflammatoryimmunoregualtory activity could bemediated by pineal gland.

关 键 词：皂甙 白芍 丹皮 松果腺 关节炎 

分 类 号：R282.710.5[医药卫生—中药学]