米帕林对β－肾上腺素能受体的作用  

Effects of mepacrine on β-adrenergic receptor

作　　者：邢成[1] 季少平[1] 王鲁明[1] 吕宝璋[1] 

机构地区：[1]北京军事医学科学院基础医学研究所

出　　处：《中国药理学与毒理学杂志》1994年第4期307-308,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金

摘　　要：米帕林对β－肾上腺素能受体的作用邢成，季少平，王鲁明，吕宝璋（北京军事医学科学院基础医学研究所，北京１００８５０）米帕林（ｍｅｐａｃｒｉｎｅ，Ｍｅｐ）是磷脂酶Ａ，及磷脂酶Ｃ的抑制剂，也是一种膜稳定剂［１］．我们曾证实它在磷脂代谢和对β－肾上腺素能受体...In order to identify the effects ofmepacrine on β-adrenergic receptor(β-AR). radio-ligand binding assays were taken to compare the ef-fects of mepacrine inhibiting to[3H]dihydroalprenolol([3H]DHA) binding to β-AR with that of β-ARagonist and antagonist, and the effects of mepacrineon β-AR effectors were investigated simultaneously us-ing biochemical and pharmocological methods. The re-sults demonstrated that mepacrine activate β-AR andprod uce its biologic effects,such as,increase ofintracellular cAMP level.decrease of content of liverglycogen,enhance of lipolysis of adipocyte and relaxa-tion of uterine smooth muscle.These data indjcatedthat mepacrine mav be one of the β-AR agonists.

关 键 词：米帕林 肾上腺素能 受体 药理学 

分 类 号：R966[医药卫生—药理学]