血小板在气道速发型过敏反应中的作用及阿魏酸钠的影响  

Role of platelets in airway immediate hypersensitivity andeffects of sodium ferulate

作　　者：徐小欧 张丽芬[1] 杨秋火 卞如濂[1] 

机构地区：[1]浙江医科大学神经生物学实验室

出　　处：《中国药理学与毒理学杂志》1994年第4期256-259,共4页Chinese Journal of Pharmacology and Toxicology

摘　　要：应用特异的兔抗豚鼠血小板血清耗竭脉鼠血小板，再予以卵白蛋白攻击后，诱发气道速发型变态反应，发现血小板耗竭后可明显抑制卵白蛋白所致的肺阻力增高，但对肺动态顺应性无明显影响，说明血小板在豚鼠气道速发型变态反应中起主要作用，推测其作用部位主要在大气道血小板活化因子的拮抗剂ＷＥＢ２０８６不能对抗卵白蛋白所致的肺阻力增高和肺动态顺应性的下降，而阿魏酸钠对此有抑制作用。The effects of platelet depletion withrabbit anti-guinea pig platelet serum on the airway im-mediate hypersensitivity induced by ovalbumin in guinea pigs were investigated. Platelel depletion inhibitedenhanced ovalbumin-induced lung resistance. but hadno effect on lung dynamic compliance. suggesting thatplatelets might play an important role in the airway im-mediate hypersensitivity in guinea pig and mainly af-fect the large airway. Platelets activating factor (PAF)is not a major niediator in the airway immediatehypersensitivity. because PAF antagonist. WEB2086,did not inhibit enhanced ovalbumin induced lung re-sistance and decreased lung dynamic compliance, butsodium ferulate did. suggesting sodium ferulate mighthavc anti allergic effect, though it has no effect onPAF induced bronchospasm.

关 键 词：血小板 变态反应病 免疫学 阿魏酸钠 气道速发型 

分 类 号：R593.1[医药卫生—内科学] R976[医药卫生—临床医学]