幽门螺杆菌感染对肝硬化患者高氨血症的影响  

The effect of Helicobacter pylori infection on hyperammonaemia in liver cirrhosis

作　　者：史崇明 迟若虹 宋波[2] 

机构地区：[1]烟台市卫生防疫站,山东烟台264000 [2]烟台毓璜顶医院,山东烟台264000

出　　处：《中国微生态学杂志》2005年第3期186-187,共2页Chinese Journal of Microecology

摘　　要：目的探讨幽门螺杆菌(Hp)感染对肝硬化患者血氨浓度的影响。方法51例确诊为Hp阳性的肝硬化患者为阳性组,27例Hp阴性的肝硬化患者为阴性组,40例Hp阳性的消化性溃疡或胃炎患者为对照组。分别检验3组的血氨浓度并进行比较,应用三联法治疗1周,于4周后再测定3组的血氨并进行比较。结果阳性组与阴性组、对照组血氨浓度相比差异有显著性(P<0.01)。阴性组与对照组相比差异无显著性(P>0.05),阳性组治疗前后血氨浓度变化差异有显著性(P<0.01)。阳性组不同肝功能分级组血氨浓度之间差异有显著性(P<0.05);阴性组不同肝功能分级组血氨浓度之间差异无显著性(P>0.05)。结论幽门螺杆菌感染可导致肝硬化患者血氨的升高,根除Hp后可使血氨水平明显下降。Objective To study Helicobacter pylori (Hp) infection on ammonia concentrations in patients with cirrhosis. Methods Group A was consisted of 51 cases of cirrhotic patients without Hp infection.Group B included 27 cases of cirrhotic patients without Hp infection.Group C was patients with peptic ucler or gastritis with Hp infection.Each patient in all groups was tested and compared with change in serum ammonia concentration before and 4 weeks after Hp eradication therapy.Results The serum ammonia concentration in Group A was significantly higher than Group B and Group C (P<0.01). While there was no difference between Group B and Group C (P>0.05). After eradication therapy for Hp, ammonia concentration in Group A was lower apparently (~P<0.01 ). In Group A, the serum ammonia concentration was increased as Child-Pugh classification from A to C (~P<0.05 ). While there was no difference in Group B (~P>0.05 ).Conclusions Hp infection was closely related with hyperammonaemia in patents with liver cirrhosis. The serum ammonia concentration was decreased after Hp eradication.

关 键 词：幽门螺杆菌 肝硬化 患者 感染 氨浓度 消化性溃疡 显著性 浓度变化 肝功能 阳性 HP 血氨 对照 治疗 行比 比差 级组 

分 类 号：Q785[生物学—分子生物学] S858.292[农业科学—临床兽医学]