AFP、AFU、Y-GT在肝癌诊断及鉴别中的临床价值  

Associated detection of AFP、AFU、γ-GT improves in liver cancer diagnosis and differentiate valuel

作　　者：付松柏[1] 周玉珠[1] 周琳[1] 

机构地区：[1]哈尔滨242医院

出　　处：《航空航天医药》2005年第2期3-4,共2页Aerospace Medicine

摘　　要：目的:探索四种血清肿瘤标记物对肝病的诊断及临床意义。方法:应用放射免疫法检测甲胎蛋白(AFP)、速率法检测岩藻糖苷酶(AFU)、血清β2微球蛋白(β2-MG)。测定原发性肝癌50例、肝硬化患者50例、其他恶性肿瘤患者50例、健康体检患者60例血清。结果:原发性肝癌各项指标与其他恶性瘤组、肝硬化组比较除β2-MG无差异(P>0.05)外,其他三项都有显著差别。分别(P<0.01)或有差异(P<0.05)。原发性肝癌组单项AFP、AFU、β2-MG、γ-GT。阳性检出率分别是66%、78%、80%、82%。AFP、AFU、γ-GT,诊断符合率分别是81%、84%、79%。联合检测敏感性达98%,比单项AFP(66%)检测敏感性比较差异有显著意义(P<0.01)结论:联合测定AFP、AFU、γ-GT,可提高对肝癌阳性诊断率,并可提高对肝病鉴别诊断价值。Objective:to investigate four kinds of serum tumor marker on the liverish diagosis and its clinica significance.Methods:Detecting the AFP with rediative and immunologic ways.the liveliness of AFU、γ-GT with speed method.theβ_2-MG with transmission comparison,determined 50 patients on idiopathy liver cancer,50 patients on hepatocirrhosis,50 patients on other malignancy and 60 physical checkup serm.Results:except β_2-MG there were significant difference between idiopathy Liver Cancer group to other there groups respectively P<0.01 or P<0.05.the AFP、AFU、β_2-MG、γ-GT pathologic examime rate of idiopathy Liver Cancer group were 66%、78%、80%、82%.coincident rate before cure 81%、84%、79%、respectively.Associated detection sensitiveness get to 98%、simple detection of AFP was 66%、the differentiate of detective sensitiveness has significant meaning(P<0.01).Conclussions:Associated detection of AFP、AFU γ-GT can improve diagnosis rate of Liver Cancer and enhance hepatic diseaes distinguish value.

关 键 词：原发性肝癌 肝硬化 肿瘤标记物 临床义意 

分 类 号：R446.1[医药卫生—诊断学]