早期急性心梗溶栓时凯时对心肌的保护作用  

The protection function of Lipo- PGE1 on acute myocardial infarction during dissolving thrombus

作　　者：朱新业[1] 杜立峰[1] 王子颖[1] 周晓荣[1] 

机构地区：[1]西安交通大学第二医院急诊科,西安710004

出　　处：《陕西医学杂志》2005年第6期692-693,共2页Shaanxi Medical Journal

摘　　要：目的:探讨脂质携载前列腺素E1(Lipo-PGE1,商品名:凯时)在急性心梗溶栓时抗心肌再灌注损伤及再灌注心律失常的作用。方法:30例急性心梗患者随机分成2组。两组均给重组组织型纤维蛋白溶酶原激活剂(rt-PA)进行溶栓,治疗组15例加用凯时20μg静脉推注,心电监护观察2h内症状缓解情况及心电图改变,心肌射血分数(EF)变化并判断冠状动脉再通率。结果:两组溶栓后冠状动脉再通率,1周后再梗死率,5周内病死率有显著性差异(P<0.05)。溶栓前后各组EF值变化显著性差异(P<0.05)。凯时可提高冠状动脉再通率,降低1周后再梗死率及5周内病死率,心肌射血分数明显提高。结论:在急性心肌梗塞溶栓时加用凯时能有效降低再灌注心肌损伤,保护心肌。Objective:To investigate the effect of Lipo- PGE1 on anti- reperfusion- injuries of heart and reperfusion arrthythmia in acute myocardial infarction. Methods:30 cases were divided into 2 groups randomly, Lipo- PGE1 were injected intravenously in 15 cases of the treatment group,and in 15 cases of control group, Lipo- PGE1 weren't used.All cases in both groups were given rtPA to dissolve thrombus. The incidence rate of arrthythmia, remission of symptoms in 2 hours and changes of electrocardiogram were observed. Results:The incidence rates of reperfusion injuriy and arrthythmia in treatment group were obviously lower than that of control group.Conclusion: Applying Lipo- PGE1 during dissolving thrombus can decrease the reperfusion arrthythmia and injuries effectively in the cases of acute myocardial infarction,protected the heart muscles and increase the EF.

关 键 词：急性心梗 凯时 保护作用 冠状动脉再通率 纤维蛋白溶酶原激活剂 再灌注心律失常 心肌再灌注损伤 再灌注心肌损伤 显著性差异 早期 急性心肌梗塞 射血分数 再梗死率 重组组织型 心电图改变 前列腺素 静脉推注 症状缓解 监护观察 

分 类 号：R542.22[医药卫生—心血管疾病] R587.2[医药卫生—内科学]