核因子-κB在乙型肝炎病毒相关性肾炎中的核转位表达及其意义  

Expression of nuclear transcription factor-kappaB's nuclear translocation and its significance in hepatitis B virus associated nephritis

作　　者：崔继红[1] 张静[1] 刘彦仿[1] 杨守京[1] 张传山[1] 程虹[1] 

机构地区：[1]第四军医大学西京医院病理科,陕西西安710033

出　　处：《西北国防医学杂志》2005年第3期161-163,F003,共4页Medical Journal of National Defending Forces in Northwest China

基　　金：国家自然科学基金资助项目(30400213)

摘　　要：目的:了解乙型肝炎病毒相关性肾炎(HBVGN)肾组织中核因子-KappaB(NF-κB)核转位表达并探讨其在HBVGN肾病发生中的作用。方法:采用微波免疫组织化学染色的方法,对30例HBVGN和5例正常肾组织中的NF-κB亚基p65表达进行检测。结果:在HBVGN病例中,有80%(24/30)的肾组织表现为不典型膜性肾病;NF-κB的核转位表达较正常肾组织显著升高(P<0.05),位于肾小球上皮细胞、内皮细胞及系膜细胞和肾小管上皮细胞的胞核内。结论:肾组织内NF-κB的核转位表达增多可能与HBV的感染有关,NF-κB可能参与了HBV引发HBVGN的发生过程。Objective:To investigate the expression of nuclear translocation of nuclear transcription factor-kappaB (NF-κB) in hepatitis B virus associated nephritis (HBVGN) tissues and its significance in the pathogenesis of HBVGN. Methods: The microwave-based immunohistochemistry was used to detect the expression of NF-κB p65 in 30 cases of HBVGN and 5 cases of normal renal tissues. Results:80% (24/30) of HBVGN renal tissues showed non-typical membranous nephropathy. Compared with normal renal tissues, the expression of NF-κB's nuclear translocation was increased markedly in HBVGN (-P-<0.05). The nuclear expression of NF-κB was found in some endothelial, epithelial, mesangial cells of glomerules and epithelial cells of tubules. Conclusion:The high expression of NF-κB's nuclear translocation maybe has some relationship with the infection of HBV. NF-κB maybe take part in the pathogenesis of HBV inducing HBVGN.

关 键 词：乙型肝炎病毒相关性肾炎 核因子-ΚB 核转位 免疫组织化学 

分 类 号：R512.6[医药卫生—内科学]