6种地衣成分的海虾幼虫致死性生物测定  

Brins shrimp lethality bioassay of six lichens constituents

作　　者：丁东宁[1] 靳菊情[1] 阎宝琦 刘次伯[1] 

机构地区：[1]西安医科大学药学系,陕西教育学院生物系

出　　处：《中国药学杂志》1994年第4期211-213,共3页Chinese Pharmaceutical Journal

摘　　要：本研究采用海虾幼虫（ｂｒｉｎｅｓｈｒｉｍｐ）致死性生物测定法，对６种地衣的三氯甲烷提取物、单体化合物、多糖等１９个样品进行了抗癌活性的初步筛选。结果长松萝、太白花的三氯甲烷提取物，Ｒ－（＋）松萝酸、Ｓ－（－）松萝酸、红石耳Ⅱ具有较强的生物活性，Ｓ－（－）松萝酸钠活性最强ＬＣ＿（５０）为５．５μｇ／ｍｌ。６种地衣多糖均未显示生物活性。Using brine shrimp lethality bioassay,we sieved anticancer activity of 19 samplesfrom chlorofom extracts pure compounds,and polysaccharides of 6 lichens, The chlorofom ex-tracts of Usnea longissina and Cladonia stellaris,R-(+)usnic acid,S-(-)usnic acid, and umbili-caria hypococcinea Ⅱ were powerful bioactive.S-(-)usnic acid-Na was the most powerful bioac-tive LC_(50)=5. 5μg/ml.Polysaccharides of 6 lichens were not bioactive.

关 键 词：海虾幼虫 地衣 多糖 松萝酸钠 

分 类 号：R282.710.5[医药卫生—中药学]