聚氰基丙烯酸正丁酯毫微球中米托蒽醌的含量测定  

Determination of mitoxantrone in polybutylcyanoacrylate nanospheres

作　　者：张志荣[1] 廖工铁[1] 

机构地区：[1]华西医科大学药学院

出　　处：《中国药学杂志》1994年第7期422-424,共3页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金

摘　　要：用混合溶剂将米托蒽醌聚氰基丙烯田正丁酯毫微球溶解后，采用分光光度法测定其中的米托蒽醌的含量。测定波长为６６０ｎｍ，测定线性范围为０．３～２．０ｍｇ／１００ｍｌ，回收率为９９．６１％，ＲＳＤ为０．５９％（ｎ＝３）。方法准确可靠，简便快速，可供该类毫微球剂或微球剂中药物含量测定参考。We determined the contents of mitoxantrone in polybutylcyanoacrylate nanospheresby spectrophotometry after dissolving the mitoxantrone-polybutylcyanoacrylate nanosperes in asolvent mixture. The determining wavelength was 660nm, the linear range 0.3～2. 0mg/100ml,the average recovery of mitoxantrone in polybutylcyanoacrylate nanosperes 99. 61%, the relativestandard deviation 0.59%(n=3),and the correlation coefficient of mitoxantrone 0.9999.Themethod is accurate and simple,and can be used as a reference for other nanospheres preparations.

关 键 词：米托蒽醌 毫微球 分光光度法 

分 类 号：R927.2[医药卫生—药学]