下丘脑外侧区注射人参单体皂甙Rb＿1的抗应激作用及其机理  

Anti-stress effect and mechanism of action of ginsenoside monomer Rb_1injecting into lateral hypothalamus area of rats

作　　者：陈霞[1] 杨世杰[1] 陈立[1] 周呜 曹延年[1] 

机构地区：[1]白求恩医科大学药理教研室

出　　处：《中国药学杂志》1994年第7期401-404,共4页Chinese Pharmaceutical Journal

摘　　要：本实验通过在正常及急性失血大鼠下丘脑外侧区（ＬＨ）注射人参单体皂甙Ｒｂ＿１（Ｒｂ＿１），以血压为指标，探讨了Ｒｂ＿１的中枢性抗应激作用及其机理。在正常大鼠ＬＨ注射Ｒｂ＿１μｇ，其平均动脉压（ＭＡＰ）明显升高。在急性失血造成急性应激状态的大鼠，ＬＨ注射Ｒｂ＿１６μｇ后，其ＭＡＰ上升程度显著高于正常给药组。同时血浆皮质醇测定结果显示，给Ｒｂ＿１组明显高于对照组，而预先注射地塞米松后ＬＨ注射Ｒｂ＿１则不再引起急性失血大鼠血压升高。提示ＬＨ注射Ｒｂ＿１有明显的抗应激作用。The anti-stress effect of ginsenoside monomer Rb_1 and its mechanism of action onthe central nervous system were investigated in normal and acute hemorrhage rats. The Rb_1 wasinjected into the lateral hypothalamus area(LH)of the rats. The blood pressure was recorded.Af-ter injection of Rb_1 6.6 nmol into LH of normal rats ,the mean arterial pressure(MAP)increasedsignificantly. The method of acute hemorrhage rat was used to make animals in an acute stressstate。After Rb_1 6. 6 nmol was injected into LH of the rats ,the MAP raised significantly.The re-sults of the plasma cortisol concentration showed that the plasma cortisol concentration of inject-ing Rb_1 group was higher than that of saline control group.However intraperitoneal injection ofdexamethasone did not raise the MAP in acute hemorrhage rats after injecting of Rb_1 into LH. Rb_1exmhted obviously anti-stress effect.

关 键 词：人参 单体 皂甙Rb1 下丘脑 应激 

分 类 号：R285.5[医药卫生—中药学]