HPLC同时测定人血清中10种抗癫痫及镇静催眠药物  

HPLC for simultaneous determination of ten antiepileptic and sedativ-hypnotic

作　　者：张金泉[1] 马一平 顾德良[1] 

机构地区：[1]中日友好医院药学部,阜外医院药剂科,天津第二医学院

出　　处：《中国药学杂志》1994年第8期476-478,共3页Chinese Pharmaceutical Journal

摘　　要：采用ＨＰＬＣ同时测定人血清中１０种抗癫痫及镇静催眠药物，以环己巴比妥作内标物，经乙醚提取后于Ｃ＿（１８）色谱柱分离，检测波长２５４ｎｍ，１０种药物分离良好。本法简便，灵敏度高，数据可靠，适于临床癫痫病人的血药浓度监测和中毒病人的急救诊断。A method was developed for simultaneous determination of ten antiepileptic andsedativ-hypnotic by HPLC. Cyclobarbital used as internal standard. The detector wave-length was254nm,Samples were extracted with ether and then separated by C_(18) column. Simple,sensitive,ac-curate with few interferences this method can be used in monitoring therapeutic drugs inantiepileptic patients and can give an early diagnosis to save the poisoned patient.

关 键 词：抗癫痫药 镇静药 高效液相色谱 

分 类 号：R971.6[医药卫生—药品]