主动脉夹层动脉瘤形成的生物力学机制的实验研究—主动脉在体运动与动态变形分析  

Experimental Study on Biomechanical Mechanism of Aortic Dissection—Analysis for Researching Kinematics and the Dynamic Deformation of the Aorta in Vivo

作　　者：张宏家[1] 孙衍庆[1] 李晓阳[1] 刘愚勇[1] 

机构地区：[1]首都医科大学附属北京安贞医院心外科,北京100029

出　　处：《北京生物医学工程》2005年第3期166-170,共5页Beijing Biomedical Engineering

基　　金：国家自然基金 (10 3 72 0 10 )资助

摘　　要：目的　建立动态观察主动脉在体变形数据分析模型。方法　数字图像处理系统以2 4帧s的速度对实验兔主动脉进行动态实时采集。应用多项式对主动脉的边界进行函数表达,并用最小二乘拟合方法拟合得到主动脉的边界,应用计算机软件自动跟踪、处理、测量,从而确定每一张图片上主动脉弓的边界,并进行测量。结果　实验兔主动脉直径变化具有周期性;实验兔的动脉血管壁具有一定的锥度。在每个心动周期,主动脉变形幅度最大处位于降主动脉峡部。结论　本文所研究的测量方法可解决主动脉动态变形的问题,并在技术上和方法上保证了测量的准确性和精确性,可以定量的分析主动脉的运动和变形的规律。Objective To build an analysis method for researching the dynamic deformation of the aorta in vivo. Methods Real-time pictures of the aorta of rabbits were gathered with digital image processing system at a speed of 24 frames per second. The boundary of the aorta is expressed by a quadratic polynomial. Parameters of quadratic polynomial were calculated by the least-squares method. Software is designed to track the boundary meanwhile to measure the diameter automatically. Results The diameter of the aorta is shown periodical variety. The aorta shows itselt bit of taper. In every heart period, the max deformation scope of the aorta lies descending thoracic aortic isthmus. Conclusion The method can measure dynamic deformation of aortic.The digital image processing technique and mathematical method ensure the veracity and accuracy of the measurement. This method can be used to analyze the movement and deformation of the aorta quantificationally in vivo.

关 键 词：主动脉夹层动脉瘤 动态变形 生物力学 数字图像处理系统 肿瘤形成 

分 类 号：R543.16[医药卫生—心血管疾病] R318.01[医药卫生—内科学]