磁性药物靶向治疗中磁流体的体外动力学研究  

In Vitro Studies on Hydrodynamics of Ferrofluids Used in Magnetic Drug Targeting

作　　者：徐华[1] 宋涛[1] 

机构地区：[1]中国科学院电工研究所生物医学工程部,北京100080

出　　处：《北京生物医学工程》2005年第3期204-208,236,共6页Beijing Biomedical Engineering

基　　金：中国科学院知识创新工程项目 (KJCX1 0 9)资助

摘　　要：根据三维有限元(FEA)电磁场计算软件的仿真和计算,自制出实验所需的产生高梯度磁场的永磁磁体。体外模拟人体血管系统,检测不同流速状态、不同磁场强度和梯度下磁流体在磁区的滞留率,研究影响磁流体滞留的主要因素;简化磁粒受力模型,理论研究磁流体的流体动力学,并提出一种理论估算磁流体在靶区的滞留率的方法。实验结果表明理论分析和实验结果基本吻合,磁流体在靶部位的滞留率主要和磁粒的大小、磁粒的磁化强度、载液的流速、外加磁场强度和梯度有关。The magnet which generates high magnetic field gradient was developed by the FEA electromagnetic computing software. An in vitro system simulating human circulatory was used to test the retention of ferrofluid under the different flow rate of medium, the magnitude and gradient of magnetic field, and then confirmed the main factors to affect the retention of ferrofluid. Additionally the hydrodynamics of ferrofluid as drug carriers was theoretically studied by the simplified model of forces exerted on ferrofluids, and the retention of ferrofluid in the target was estimated under various conditions. The results showed the calculation results coincided with experimental results in general, and the retention of ferrofluids was related to the flow rate of medium, the magnitude of magnetic field and magnetic field gradient.

关 键 词：磁性药物 靶向治疗 磁流体 滞留率 体外动力学 

分 类 号：R318.01[医药卫生—生物医学工程]