2－羧乙基锗倍半氧化物药代动力学研究  

Pharmacokinetic Studies of 2-Carboxyetbyl germanium Sesquioxide

作　　者：詹丽芬[1] 张玉芝[1] 赫梅生[1] 李宁和 陈子易[1] 靳德翔 张凯恩 史海[1] 

机构地区：[1]中国医科大学药理学教研室,中国医科大学化学检测出中心实验室,沈阳军区军事医学研究所

出　　处：《中国医科大学学报》1994年第2期83-87,共5页Journal of China Medical University

摘　　要：在分别单剂量静脉应用２４ｍｇ／ｋｇ，１２０ｍｇ／ｋｇ，６００ｍｇ／ｋｇ和单剂量口服１２０ｍｇ／ｋｇ后，用原子吸收光谱，ＩＢＭＰＣ微机和３Ｐ８７程序研究２－羧乙基锗倍半氧化物（Ｇｅ－１３２）于家兔体内的药动学参数。结果表明，各静注剂量组的时－浓曲线均属一级动力学，二房室模型，消除相半衰期接近，约为７５ｍｉｎ。中高剂量组的表观分布容积分别是０．１９９５Ｌ／ｋｇ和０．２０４１Ｌ／ｋｇ，二者比较接近。而低剂量组的表观分布容积是２．３１８Ｌ／ｋｇ。随着用药剂量的增加，药物的消除动力学没有变成零级动力学。口服Ｇｅ－１３２１２０ｍｇ／ｋｇ后，峰值时间为２．９５ｈ，生物利用度为１８％。he pharmacokinetic parameters of 2-carboxyethylgermanium sesquioxide(Ge-132) were investi-gated by 180-80 AAS and computer 3P87 programs after a single intravenous administration of 24 , 120,600 mg /kg of Ge-132 respectively and a single oral administration of 120mg/kg of Ge-132 in rabbits.The results showed that the time-concentration curves of Ge-132 in different dosage-groups all belonedto the first order kinetics,the two-compartment models,The half-life time of elimination phase wasguite near they were 75min approximately. The apparent volumes of distribution were 0.1995 and 0.2041 L/kg at doses of both 120 and 600 mg/kg respectively,and 2.318 L/kg at a dose of 24 mg/kg in-traveneously. The elimination kinetics of the drug didn′ t change into zero order kinetics as the dosage ofthe drug was increased.The peak time was 2. 95 h after a oral administration of 120 mg/kg of Ge-132.The bioavailability was 18%.

关 键 词：药代动力学 羧乙基 锗倍半氧化物 

分 类 号：R979.1[医药卫生—药品]