皮毛粉尘对大鼠肺纤维化作用的实验研究  

The Experimental Study on Fibrogenic Effects of Fur Dusts on Rat Lungs

作　　者：陈杰[1] 楼介治[1] 郭晓芳[1] 孟德成[1] 吴凤全[1] 蔡响生 

机构地区：[1]中国医科大学尘肺研究室,锦州职业病防治所

出　　处：《中国医科大学学报》1994年第2期112-114,125,共4页Journal of China Medical University

摘　　要：用皮毛作业现场粉尘（游离ＳｉＯ２）含量分别为０．６％，０．７％和１７．６％）经大白鼠气管内染尘，于染尘后１、３、６、１２个月作肺组织病理学检查及全肺胶原含量测定。实验动物早期主要为间质肺炎样改变和呼吸道炎症。实验晚期时，游离ＳｉＯ２含量低于１％的皮毛粉尘只表现为轻度肺间质纤维增生，而游离ＳｉＯ２含量为１７．６％的皮毛粉尘在肺内有典型的纤维结节形成，肺组织超微结构有相应改变。证明皮毛粉尘具有一定致纤维化作用，致纤维化作用的强弱与粉尘中游离ＳｉＯ２含量有关，提示应引起对皮毛工人尘肺的重视。he rats were injected intratracheally with fur dusts(silica content was 0.6%,0.7%and 17.6%respectively) from work-enviroment.At the end of 1,3,6,12 months after dust injection,histologicalchanges of lung were examined and lung collagen contents were detected.The result showed thatinterstitial pneumonitis and inflammation of airway were observed in early stage ,At the end of 12months after dust injection,the fur dusts with lower silica content.(less.than 1%)caused slightlyinterstitial proliferation in lung ,whereas fur dust with higher silica content( 17.6%)caused typicalfibrotic nodules. The ultrastructure of lungs had parallel changs. Based on above experimental data,itmight conclude that the fibrogenic effects of fur dust were mainly related to silica content,and that thepneumoconiosis due to fur dust exposure should not be ignored.

关 键 词：皮毛粉尘 肺纤维化 尘肺 

分 类 号：R598.2[医药卫生—内科学]