缺氧时肺腺泡内动脉中膜平滑肌细胞表型变化  

The Phenotypic Change of Smooth Muscle Cells in the Media of Pulmonary Intra-acinar Arteries during Hypoxia

作　　者：宋为[1] 蔡英年[1] 邓希贤[1] 龚伊红[1] 董继红[1] 

机构地区：[1]中国医学科学院,中国协和医科大学基础医学研究所

出　　处：《中国医学科学院学报》1994年第4期255-258,共4页Acta Academiae Medicinae Sinicae

摘　　要：观察了减压缺氧不同时间Ｗｉｓｔａｒ大鼠肺腺泡内动脉中膜平滑肌细胞（ＳＭＣ）表型情况。主要发现：（１）缺氧３～４０ｄ组，肺动脉压（ＰＡＰ）持续显著升高，右心肥厚程度逐渐加重。（２）缺氧１～５ｄ组，中膜ＳＭＣ仍为收缩表型，胞间胶原分布略有所增加；缺氧７ｄ组，于近内弹力层处少数ＳＭＣ转变为合成表型，还有些细胞向合成表型部分转化，胞间胶原增多；缺氧１４～４０ｄ组，与合成分泌功能有关细胞器及胶原分布仍较缺氧１～５ｄ组ＳＭＣ为多，少数ＳＭＣ仍呈部分合成表型，大多数ＳＭＣ又出现收缩表型的特征。提示：随缺氧时间延长，ＩＡＡ中膜ＳＭＣ表型可能存在动态变化，但与ＰＡＰ的变化不呈平行关系。原因有待探讨。The phenotypic change of smooth muscle cells(SMCs) in the media of pulmonary intra acinar arteries(IAA) was observed in rats during hypoxia. From 3 to 40 exposure days,pul monary arterial pressure(PAP) and right ventricular hypertrophy increased parallely.From 1 to 5 exposure days,SMCs still displayed the“contractile”phenotype,but the amount of intercellular collagen slightly increased. After 7 exposure days,some medial SMCs changed into the“fully”or“partially”“synthetic”phenotype with an excess of intercellular collagen.From 14 to 40 exposure days,other than some SMCs of partially“synthetic”phenotype, a great number of SMCs acquired the“contractile”phenotype characteristics, but the synthetic and secretive organelles and intercellular collagen were still more than those in the groups from 1 to 5 exposure days. Our results suggested that along with the prolongation of hypoxic exposure, the kinetic changes of SMC phenotype might not parallel with PAP change.

关 键 词：缺氧 肺腺泡内动脉 平滑肌细胞 

分 类 号：R563[医药卫生—呼吸系统]