抗分化HL－60／RA和分化敏感HL－60细胞对阿糖胞苷、三尖杉酯碱等抗肿瘤药物细胞毒作用的敏感性比较  

Comparison of the Sensitivity of Retinoic Acid Sensitivity of Resistant HL-60 Cell Lines to Several Anti-leukemia Drugs

作　　者：李林[1] 夏丽娟[1] 韩锐[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药物研究所

出　　处：《中国医学科学院学报》1994年第6期469-472,共4页Acta Academiae Medicinae Sinicae

基　　金：中国医学科学院青年基金

摘　　要：抗分化ＨＬ－６０／ＲＡ和分化敏感ＨＬ－６０细胞对阿糖胞苷、三尖杉酯碱等抗肿瘤药物细胞毒作用的敏感性比较李林，夏丽娟，韩锐（中国医学科学院，中国协和医科大学药物研究所，北京１０００５０）急性早幼粒细胞白血病（ＡＰＬ）的全反式维甲酸（ａｌｌ－ｔｒａｎｓｒ...Abstract By using MTT and trypan blue exclusion assay,the sensitivity of retinoic acid sensitive HL-60 and resistant HL-60/RA cell to six anti-leukemia drugs such as RA,Ara-c,harringtonine was compared;It was found that all five drugs except RA exhibited an approximately equivalant IC50 to HL-60 and HL-60/RA cells,The results suggest that tumor cells may not develop resistance to differentiation inducer and cytotoxic anti-tumor agent parallel.It also suggests that it is reasonable to use a combination of differentiation and cytotoxic antileukemia agents concomitantly or sequentially.

关 键 词：维甲酸 阿糖胞苷 三尖杉酯碱 抗肿瘤 

分 类 号：R979.1[医药卫生—药品]