Tissue distribution and excretion of ^(125)I-lidamycin in mice and rats  

作　　者：You-PingLiu Quan-ShengLi Yu-RongHuang Chang-XiaoLiu 

机构地区：[1]NationalKeyLaboratoryofPharmacokineticsandPharmacodynamics,TianjinInstituteofPharmaceuticalResearch,308An-ShanWestRoad,Tianjin300193,China [2]LaboratoryofDrugMetabolismPharmacokinetics,ShenyangPharmaceuticalUniversity,103WenhuaRoad,Shenyang110016,LiaoningProvince,China [3]NationalKeyLaboratoryofPharmacokineticsandPharmacodynamics,TianjinInstituteofPharmaceuticalResearch,Tianjin300193,China

出　　处：《World Journal of Gastroenterology》2005年第21期3281-3284,共4页世界胃肠病学杂志（英文版）

基　　金：Supported by the National High Technology Research and Development Program of China (863 Program), No. 2003AA2Z347D

摘　　要：AIM: To investigate the tissue distribution, urinary and fecal excretions of 125I-lidamycin (125I-C-1027) in mice and its biliary excretion in rats. METHODS:The total radioactivity assay (RA method) and the radioactivity assay after precipitation with 200 mL/L trichloroacetic add (TCA-RA method) were used to dete-rmine the tissue distribution,and the urinary and fecal excretions of 125I-C-1027 in mice and its biliary excretion in rats. RESULTS:Tissue concentrations reached the peak at the fifth minute after administration of 125I-C-1027 to mice. The highest concentration was in kidney, and the lowest in brain at all test-time points. The organs of the concentrations of 125I-C-1027 from high to low were kidney, lung, liver, stomach, spleen, uterus, ovary, intestine, muscle, heart, testis, fat, and brain in mice. The accumulative excretion amounts of 0-24 h, and 0-96 h after administration of 125I-C-1027 were 68.36 and 71.64% in urine, and 2.60 and 3.21% in feces of mice, respectively, and the accumulative excretion amount of 0-24 h was 3.57% in bile in rats. CONCLUSION: Our results reflect the characteristics of the tissue distribution, urinary and fecal excretions of 125I-C-1027 in mice and the biliary excretion of 125I-C-1027 and its metabolites in rats, and indicate that 125I-C-1027 and its metabolites are mainly distributed in kidney, and excreted in urine.AIM: To investigate the tissue distribution, urinary and fecal excretions of 125I-lidamycin (125I-C-1027) in mice and its biliary excretion in rats.METHODS: The total radioactivity assay (RA method) and the radioactivity assay after precipitation with 200 mL/L trichloroacetic acid (TCA-RA method) were used to dete-rmine the tissue distribution, and the urinary and fecal excretions of 125I-C-1027 in mice and its biliary excretion in rats.RESULTS: Tissue concentrations reached the peak at the fifth minute after administration of 125I-C-1027 to mice. The highest concentration was in kidney, and the lowest in brain at all test-time points. The organs of the concentrations of 125I-C-1027 from high to low were kidney, lung, liver, stomach, spleen, uterus, ovary, intestine, muscle, heart, testis, fat, and brain in mice. The accumulative excretionamounts of 0-24 h, and 0-96 h after administration of125I-C-1027 were 68.36 and 71.64% in urine, and 2.60 and 3.21% in feces of mice, respectively, and the accumulative excretion amount of 0-24 h was 3.57% in bile in rats.CONCLUSION: Our results reflect the characteristics of the tissue distribution, urinary and fecal excretions of 125IC-1027 in mice and the biliary excretion of 125I-C-1027and its metabolites in rats, and indicate that 125I-C-1027and its metabolites are mainly distributed in kidney, and excreted in urine.

关 键 词：Distribution EXCRETION LIDAMYCIN C-1027 RA method TCA-RA method 

分 类 号：R818.73[医药卫生—放射医学] R57[医药卫生—临床医学]